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Review
. 2024 Sep 23;9(1):252.
doi: 10.1038/s41392-024-01967-1.

Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer's and tauopathies

Natja Haag #  1 , Juliane Bremer #  2 , Hans Zempel #  3   4   5
Affiliations
Review

Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer's and tauopathies

Natja Haag et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests

Figures

Fig. 1
Fig. 1
Sex-dependent neutrophil-mediated activation of microglia via IL-17F to IL-17RA signaling results in impaired amyloid-beta plaque clearance and enhanced neurodegeneration in female APOE ε3/4 carriers. Left: Physiological activation of microglia towards a neuroprotective and plaque-clearing state (MGnD/DAM microglia) in asymptomatic aged individuals (e.g. APOE ε3/3 genotype or male APOE ε3/4 carriers). Right: Pathological signaling in female APOE ε3/4 carriers of neutrophils to microglia resulting in microglia unable to clear amyloid-beta plaques, which in turn contributes to the formation of dense-core and neuritic plaques, and neurodegeneration. Created with BioRender.com
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