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. 2024 Sep 9:15:1449133.
doi: 10.3389/fmicb.2024.1449133. eCollection 2024.

Perspective: on the future of fecal microbiota transplantation

Olaf F A Larsen  1 , Robert J M Brummer  2
Affiliations

Perspective: on the future of fecal microbiota transplantation

Olaf F A Larsen et al. Front Microbiol. .

Abstract

Fecal Microbiota Transplantation (FMT) has shown to possess impressive potential benefit for a wide range of clinical indications. Due to its inherent safety issues and efficacy constraints, the use of personalized FMT analogs could be a promising avenue. The development of such analogs will require a detailed understanding of their functionality, encompassing not only microbe-host interactions of the microbial taxa that are involved, but also of the ecological dimensions of the analogs and an overview of the gastrointestinal sites where these relevant microbial interactions take place. Moreover, characterization of taxa that have been lost due to diminished exposure to beneficial microbes, as a consequence of Western lifestyle, may lead to creation of future FMT analogs with the capacity to restore functionalities that we have lost.

Keywords: One Health; analogs; fecal microbiota transplantation; gut microbiota; personalized; probiotics.

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Conflict of interest statement

OL is Senior Manager Science at Yakult Nederland B. V. RB is also a member of the Scientific Advisory Board of The Akkermansia Company.

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