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[Preprint]. 2024 Sep 11:2024.09.10.24313399.
doi: 10.1101/2024.09.10.24313399.

Rapid Decline of Mpox Antibody Responses Following MVA-BN Vaccination

Ai-Ris Y Collier  1 , Katherine McMahan  1 , Catherine Jacob-Dolan  1 , Jinyan Liu  1 , Erica N Borducchi  1   2 , Bernard Moss  2 , Dan H Barouch  1
Affiliations

Rapid Decline of Mpox Antibody Responses Following MVA-BN Vaccination

Ai-Ris Y Collier et al. medRxiv. .

Update in

Abstract

The replication-incompetent modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN; Jynneos) was deployed during the 2022 clade IIb mpox outbreak. On August 14, 2024, the World Health Organization declared the mpox clade Ib outbreak in the Democratic Republic of the Congo a public health emergency of international concern, which has raised the question about the durability of vaccine immunity after MVA-BN vaccination. In this study, we show that the MVA-BN vaccine generated mpox serum antibody responses that largely waned after 6-12 months.

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Conflict of interest statement

Conflicts of Interest The authors report no conflicts of interest.

Figures

Figure 1.
Figure 1.
Serum mpox binding and neutralizing antibody responses following 2-dose and 1-dose MVA-BN vaccination
See this image and copyright information in PMC

References

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