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. 2024 Dec 12;144(24):2554-2557.
doi: 10.1182/blood.2024026605.

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Sun Loo  1   2   3 , Nicola Potter  4 , Adam Ivey  5 , Jenny O'Nions  6   7 , Roderick Moon  5 , Jelena Jovanovic  4 , Chun Y Fong  8 , Natasha S Anstee  2   3 , Ing Soo Tiong  1   9 , Jad Othman  4   10 , Chong Chyn Chua  2   3   11 , Hanna Renshaw  6 , Robert Baker  6   7 , Shaun Fleming  12 , Nigel H Russell  10 , David Ritchie  1   13 , Ashish Bajel  1   13 , Hsin-An Hou  14 , Richard Dillon  4   10 , Andrew H Wei  1   2   3
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Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Sun Loo et al. Blood. .

Abstract

Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).

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