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. 2024 Dec 10;74(1):6-8.
doi: 10.1136/gutjnl-2024-333222.

Alcohol-associated hepatitis: a neutrophile disease?

Maximilian Joseph Brol  1 , Ali Canbay  2 , Jonel Trebicka  3   4
Affiliations

Alcohol-associated hepatitis: a neutrophile disease?

Maximilian Joseph Brol et al. Gut. .
No abstract available

Keywords: ALCOHOL; ALCOHOLIC LIVER DISEASE; GUT IMMUNOLOGY; HEPATITIS; LIVER IMMUNOLOGY.

PubMed Disclaimer

Conflict of interest statement

Competing interests: JT has received speaking and/or consulting fees from Gore, Boehringer-Ingelheim, Falk, Genfit, Grifols and CSL Behring.

Figures

Figure 1
Figure 1. Abundance and role of ORM2 in ArLD. (A) Protein copy number of ORM2 across four major liver cell types: hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells. (B) Protein level of ORM2 in the liver and in the portal vein. For both, data are extracted from http://www.liverproteome.org/, the largest cell-type resolved human liver proteome data by MS-based proteomics hosting quantitative information about proteins across four major liver cell types: hepatocytes, sinusoidal endothelial cells, hepatic stellate cells and Kupffer cells. (C) Protein level of ORM2 in the liver of patients with ArLD classified by fibrosis according to Kleiner fibrosis score. Data are extracted from proteome data of patients with ArLD, presenting dysregulated proteome at both protein and pathway levels in liver and plasma, publicly available at http://www.liverproteome.org. ArLD, alcohol-related liver disease; ORM2, orosomucoid 2.
Figure 2
Figure 2. Schematic overview of the gut-liver axis in alcohol-associated hepatitis. Faecal MPO is increased in alcoholic hepatitis and associated with an increased 60-day mortality. ORM2 is expressed in neutrophils and is highly abundant in the portal vein. As the severity of alcoholic hepatitis increases, hepatic ORM2 levels are rising (created with BioRender.com). AH, alcohol-associated hepatitis; MPO, myeloperoxidase; ORM2, orosomucoid 2.
See this image and copyright information in PMC

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