Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 18;15(9):858-869.
doi: 10.5312/wjo.v15.i9.858.

Platelet-rich plasma for de Quervain's tenosynovitis: A systematic review and meta-analysis

Nucki Nursjamsi Hidajat  1 , Raden Moechammad Satrio Nugroho Magetsari  2 , Gregorius Steven  3 , Jethro Budiman  3 , Gregorius Thomas Prasetiyo  2
Affiliations

Platelet-rich plasma for de Quervain's tenosynovitis: A systematic review and meta-analysis

Nucki Nursjamsi Hidajat et al. World J Orthop. .

Abstract

Background: Platelet-rich plasma (PRP) injection is used as an alternative non-operative management for de Quervain's tenosynovitis (DQT) to regenerate tendon healing.

Aim: To assess and conclude the research-based study systematically to analyse the efficacy of PRP on DQT.

Methods: This systematic review used the Cochrane Handbook for Systematic Reviews and the guideline of preferred reporting items for systematic review and meta-analysis. A systematic literature search was applied to 11 databases. The authors assessed the study quality and risk of bias of each included study. Results of the meta-analysis were presented using mean difference (MD)/standardized mean difference (SMD) and 95% confidence interval (CI).

Results: The authors evaluated 275 studies found in the literature search; 12 studies met the criteria for this review, and then the study quality and risk of bias were assessed. Pooled analysis of data from two studies involving 194 subjects with DQT showed that, compared with conservative treatment, PRP injection was associated with a greater reduction in visual analog scale pain in one month and six months after treatment (MD: -0.67, P value < 0.00001; MD: -1.16, P value < 0.00001) and the increase of Mayo's wrist score in one month and six months after treatment (SMD: 3.72, P value < 0.00001; SMD: 4.44, P value < 0.00001).

Conclusion: PRP can be used as an alternative non-operative treatment for DQT due to the tissue regenerative effect of PRP.

Keywords: De Quervain’S disease; De Quervain’S tenosynovitis; Platelet-rich plasma; Stenosing tenosynovitis.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
Figure 2
Figure 2
ROB 2: Shoma FK, 2023[11].
Figure 3
Figure 3
Forest plots of the comparison between platelet-rich plasma injection and conservative treatment. A: Visual analogue scale (VAS) pain at first month after treatment; B: VAS pain at six months after treatment; C: Mayo’s wrist score at first month after treatment; D: Mayo’s wrist score at six months after treatment. PRP: Platelet-rich plasma.
Figure 4
Figure 4
Funnel plots of the comparison between platelet-rich plasma injection and conservative treatment. A: Visual analogue scale (VAS) pain at first month after treatment; B: VAS pain at six months after treatment; C: Mayo’s wrist score at first month after treatment; D: Mayo’s wrist score at six months after treatment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Gitto S, Draghi AG, Draghi F. Sonography of Non-neoplastic Disorders of the Hand and Wrist Tendons. J Ultrasound Med. 2018;37:51–68. - PubMed
    1. Miller LE, Parrish WR, Roides B, Bhattacharyya S. Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials. BMJ Open Sport Exerc Med. 2017;3:e000237. - PMC - PubMed
    1. Fitzpatrick J, Bulsara M, Zheng MH. The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials. Am J Sports Med. 2017;45:226–233. - PubMed
    1. Wesner M, Defreitas T, Bredy H, Pothier L, Qin Z, McKillop AB, Gross DP. A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. PLoS One. 2016;11:e0147842. - PMC - PubMed
    1. Deb D, Singh YN, Singh NB, Das R. A study to compare the efficacy, feasibility and durability of conservative & physical therapy, corticosteroid therapy and platelet rich plasma therapy in patients suffering from de quervain’s tenosynovitis: A prospective cohort study. IJMSDR. 2020;4