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. 2024 Sep 12;11(9):ofae529.
doi: 10.1093/ofid/ofae529. eCollection 2024 Sep.

Determinant of 30-Day Mortality of Pulmonary Legionellosis: Do Coinfections Matter?

Takahiro Matsuo  1 , Sebastian Wurster  1 , Ying Jiang  1 , Jeffrey Tarrand  2 , Scott E Evans  3 , Dimitrios P Kontoyiannis  1
Affiliations

Determinant of 30-Day Mortality of Pulmonary Legionellosis: Do Coinfections Matter?

Takahiro Matsuo et al. Open Forum Infect Dis. .

Abstract

We retrospectively reviewed 64 cases of cancer with pulmonary legionellosis (Legionella pneumophila in 73%). Nearly all patients received Legionella-active antibiotics, yet 30-day mortality was 23%. Independent predictors of 30-day mortality were hyponatremia, bilateral lung involvement, and Sequential Organ Failure Assessment score ≥5. Lung coinfections were common (31%) but did not significantly increase mortality.

Keywords: Legionella; cancer; coinfections; mortality outcomes; pneumonia.

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Conflict of interest statement

Potential conflicts of interest. D. P. K. reports honoraria and research support from Gilead Sciences and Astellas Pharma. He also received consultant fees from Astellas Pharma, Merck, and Gilead Sciences and is a member of the Data Review Committee for Cidara Therapeutics, AbbVie, Scynexis, and the Mycoses Study Group. All other authors report no potential conflicts.

Figures

Graphical Abstract
Graphical Abstract
Figure 1.
Figure 1.
A, Types of Legionella spp. B, Types of coinfections (20 patients with 30 copathogens isolated). MRSA, methicillin-resistant Staphylococcus aureus; RSV, respiratory syncytial virus.
See this image and copyright information in PMC

References

    1. Jacobson Kalen L, Miceli Marisa H, Tarrand Jeffrey J, Kontoyiannis Dimitrios P. Legionella pneumonia in cancer patients. Medicine (Baltimore) 2008; 87:152–9. - PubMed
    1. Han XY, Ihegword A, Evans SE, et al. Microbiological and clinical studies of legionellosis in 33 patients with cancer. J Clin Microbiol 2015; 53:2180–7. - PMC - PubMed
    1. Mikulska M, Tridello G, Hoek J, et al. Legionellosis after hematopoietic stem cell transplantation. Bone Marrow Transplant 2021; 56:2555–66. - PubMed
    1. Sivagnanam S, Podczervinski S, Butler-Wu SM, et al. Legionnaires’ disease in transplant recipients: a 15-year retrospective study in a tertiary referral center. Transpl Infect Dis 2017; 19:e12745. - PubMed
    1. Sivagnanam S, Pergam Steven A. Legionellosis in transplantation. Curr Infect Dis Rep 2016; 18:9. - PubMed