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Review
. 2024 Sep 6;28(5):537.
doi: 10.3892/ol.2024.14670. eCollection 2024 Nov.

T lymphocyte‑related immune response and immunotherapy in gastric cancer (Review)

Zhaoxiong Zhang  1 , Wenxin Zhang  1 , Xin Liu  1 , Yongjia Yan  1 , Weihua Fu  1
Affiliations
Review

T lymphocyte‑related immune response and immunotherapy in gastric cancer (Review)

Zhaoxiong Zhang et al. Oncol Lett. .

Abstract

Gastric cancer (GC) remains a global healthcare challenge because of its high incidence and poor prognosis. The efficacy of current chemotherapy regimens for advanced GC is limited. T cells, which have been implicated in the progression of GC, have a significant impact in the tumor microenvironment. With a more detailed understanding of the mechanisms underlying the cancer immunoediting process, immunotherapy may become a promising treatment option for patients with GC. Several clinical trials are currently investigating different mechanisms targeting the tumor immune response. The present review summarized T cell-involved immune responses and various immunotherapy strategies for GC.

Keywords: gastric cancer; immune checkpoint inhibitors; immunoediting; immunotherapy; tumor immune microenvironment.

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Conflict of interest statement

The authors declare that they have no competing interests.

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