Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep;92(3):e13931.
doi: 10.1111/aji.13931.

Clinical Features Between Primary Obstetric Antiphospholipid Syndrome and Non-Criteria Obstetric Antiphospholipid Syndrome and Risk Factors of Adverse Pregnancy Outcomes: A Retrospective Study of 1006 Cases

Huimin Liu  1   2   3 , Jinbiao Han  1   2 , Rui Gao  1   2   3 , Zhengyan Hu  1   2   3 , Yuanting Tang  2   4 , Lang Qin  1   2
Affiliations

Clinical Features Between Primary Obstetric Antiphospholipid Syndrome and Non-Criteria Obstetric Antiphospholipid Syndrome and Risk Factors of Adverse Pregnancy Outcomes: A Retrospective Study of 1006 Cases

Huimin Liu et al. Am J Reprod Immunol. 2024 Sep.

Abstract

Problem: To compare the clinical characteristics and pregnancy outcomes between patients with primary obstetric antiphospholipid syndrome (OAPS) and those with primary non-criteria obstetric antiphospholipid syndrome (NC-OAPS), and to identify the risk factors of adverse pregnancy outcomes in both groups.

Methods: A retrospective single-center study was performed in a university hospital of western China, including 141 patients with OAPS and 865 patients with NC-OAPS. The clinical characteristics, pregnancy complications, and obstetric outcomes of the cohorts were collected from the hospital system and were compared by univariable analysis, and the independent risk factors for adverse pregnancy outcomes (APO) were investigated by logistic regression analysis in these two populations.

Results: The OAPS patients had a significantly higher risk for stillbirths compared to the NC-OAPS patients, while the NC-OAPS group had a significantly higher risk for preterm birth and overall APO. Double aPL positivity, triple aPL positivity, and gestational hypertension were the independent risk factors for APO in OAPS patients, whereas two of the double aPL positivity subtypes, triple aPL positivity and placenta previa were independent risk factors for APO in NC-OAPS patients.

Conclusion: This study identified different rates in different APOs among OAPS and NC-OAPS patients. Additionally, this study revealed different risk factors for the development of APO between the two populations. These findings indicated that OAPS and NC-OAPS are two distinct entities of the same disease, providing new insights into the individualized management for patients with OAPS and NC-OAPS.

Keywords: adverse pregnancy outcomes; non‐criteria; obstetric antiphospholipid syndrome; risk factors; stillbirths.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. L. R. Sammaritano, “Antiphospholipid Syndrome,” Best Practice & Research Clinical Rheumatology 34, no. 1 (2020): 101463, https://doi.org/10.1016/j.berh.2019.101463.
    1. E. Esteve‐Valverde, R. Ferrer‐Oliveras, and J. Alijotas‐Reig, “Obstetric Antiphospholipid Syndrome,” Revista Clínica Española 216, no. 3 (2016): 135–145, https://doi.org/10.1016/j.rce.2015.09.003.
    1. D. R. Jayakody Arachchillage, S. J. Machin, I. J. Mackie, and H. Cohen, “Diagnosis and Management of Non‐Criteria Obstetric Antiphospholipid Syndrome,” Thrombosis Haemostasis 113, no. 01 (2015): 13–19, https://doi.org/10.1160/TH14‐05‐0416.
    1. M. G. Tektonidou, L. Andreoli, M. Limper, et al., “EULAR Recommendations for the Management of Antiphospholipid Syndrome in Adults,” Annals of the Rheumatic Diseases 78, no. 10 (2019): 1296–1304, https://doi.org/10.1136/annrheumdis‐2019‐215213.
    1. M. Barbhaiya, S. Zuily, R. Naden, et al., “2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria,” Annals of the Rheumatic Diseases 82, no. 10 (2023): 1258–1270, https://doi.org/10.1136/ard‐2023‐224609.

Substances

LinkOut - more resources