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. 2024 Oct 10;60(82):11770-11773.
doi: 10.1039/d4cc03430a.

Hydrogen-bonded frameworks for conformational analysis of reactive substrates

Alexandra M Dillon  1 , Alexander G Shtukenberg  1 , Krystyna M Demkiw  1 , K A Woerpel  1 , Michael D Ward  1
Affiliations

Hydrogen-bonded frameworks for conformational analysis of reactive substrates

Alexandra M Dillon et al. Chem Commun (Camb). .

Abstract

Guanidinium organosulfonate (GS) hydrogen-bonded host frameworks were used to trap α-halopropiophenones and α-halocyclooctanones to determine their molecular structure by single crystal X-ray diffraction. The majority of encapsulated guest molecules adopted conformations expected from computational analysis and stereochemical outcomes of Grignard reactions.

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Conflict of interest statement

Conflicts of interest

There are no conflicts to declare.

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