Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease
- PMID: 39321103
Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease
Abstract
Purpose: To review the literature on the relationship of milk fat globule EGF and factor V/VIII domain containing (MFGE8) in periodontal osteoimmunology and the clinical significance of MFGE8 in periodontal disease.
Methods: Two reviewers carried out a computer-based literature search using PubMed, Scopus, and Web of Science to identify papers published up to November 2023. The keywords used in the investigation were "MFGE8" and various words related to periodontal disease (periodontal, periodontitis, gingival, gingivitis, gingiva, and periodontium).
Results: MFGE8 plays a critical role in the etiology of periodontal disease via regulating pro-inflammatory cytokines and bone cells. In addition, MFGE8 may be applied as a diagnostic biomarker and a therapeutic target in periodontal disease.
Clinical significance: MFGE8-mediated periodontal osteoimmunology fills the vacant part of the pathogenesis in periodontal disease. This review provides a comprehensive perspective on the potential of MFGE8 in periodontal disease therapy.
Copyright©American Journal of Dentistry.
Conflict of interest statement
The authors declared no conflict of interest. This work was supported by the Natural Science Foundation of Hubei Province of China under Grant (number 2022CFB293 and 2023AFB653); the National Natural Science Foundation of China under Grant (number 81300883); Wuhan Innovative Talent Development Funds 2014; and Scientific Research Foundation for Returned Scholars, Tongji Hospital 2016.
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