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Review
. 2025 Aug;16(4):1400-1411.
doi: 10.1007/s12975-024-01300-6. Epub 2024 Sep 25.

Blood-Brain Barrier Disruption and Imaging Assessment in Stroke

Yuchen Liang #  1 , Yueluan Jiang #  2 , Jiaxin Liu  1 , Xuewei Li  1 , Xinyue Cheng  1 , Lei Bao  1 , Hongwei Zhou  3 , Zhenni Guo  4   5
Affiliations
Review

Blood-Brain Barrier Disruption and Imaging Assessment in Stroke

Yuchen Liang et al. Transl Stroke Res. 2025 Aug.

Abstract

Disruption of the blood-brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood-brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood-brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.

Keywords: Blood–brain barrier; DCE-MRI; Hemorrhagic transformation; Ischemic stroke; PCT.

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Conflict of interest statement

Declarations. Ethical Approval: Our study did not involve clinical trials on animals or humans and did not violate ethics; therefore, no further approval from the ethics committee was required. In accordance with the ethical principles outlined in the Declaration of Helsinki, all participants provided informed consent prior to participating in the study. Participants’ anonymity and confidentiality were guaranteed and participation in the study was entirely voluntary. Competing Interests: The authors declare no competing interests.

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