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Review
. 2025;25(9):664-674.
doi: 10.2174/0113895575333766240912162252.

Trace Elements in Medicinal Metallomics

Marina Orlova  1   2 , Stepan Kalmykov  1 , Tatiana Trofimova  1 , Dmitry Kuznetsov  2   3
Affiliations
Review

Trace Elements in Medicinal Metallomics

Marina Orlova et al. Mini Rev Med Chem. 2025.

Abstract

This analytical mini-review focuses on the effects of trace elements, which includes Cu, Mn, Zn, and Se, as well as some rarer microelements, on the regulation of oxidative stress in the body and of certain diseases associated with it. Synergism and competition between certain microelements have been considered a hot topic in the applied molecular pharmacology of these specific bio-effects. Some ideas for further possible directions of research are expressed. Noteworthy, metal coordinating catalytical sites of certain enzymes function as pharmacophore-forming and connecting nanostructures. These sites can be regarded as targets for various effectors, making them pharmacologically significant contributors to biocatalysis.

Keywords: Enzymatic pharmacophores; drug targets; medicinal bio-organic chemistry; metal-dependent enzymes; metallomics; trace elements..

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