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. 2024 Aug 26;16(8):e67818.
doi: 10.7759/cureus.67818. eCollection 2024 Aug.

Unraveling the Relationship Between Vitamin D and Oxidative Stress: A Cross-Sectional Study

Jayballabh Kumar  1 , Ashwani Sharma  1 , Arkajit Dasgupta  2 , Amrit Podder  1 , Govindanagouda Naregal  3 , Mohammad Kamran Iqbal  1 , Sariya Nazim  1 , Hifzu Rehman  1
Affiliations

Unraveling the Relationship Between Vitamin D and Oxidative Stress: A Cross-Sectional Study

Jayballabh Kumar et al. Cureus. .

Abstract

Introduction: Vitamin D, beyond bone metabolism, has played a significant role in various physiological processes, including modulation of oxidative stress and maintenance of vascular architecture. Oxidative stress, a state of altered balance between reactive oxygen species (ROS) and antioxidants, is a critical factor in the pathogenesis of various chronic diseases. Our study aims to explore the intricate relationship between serum vitamin D levels and markers of oxidative stress in normotensive and hypertensive individuals.

Materials and methods: A total of 108 age-matched participants (35 to 50 years) of both genders (54 males and 54 females) were included in this cross-sectional study according to the study design and assessed for their serum vitamin D level by using enzyme-linked immunosorbent assay (ELISA) method and serum malondialdehyde (MDA) level by using a spectrophotometer at 540 nm after measurement of the blood pressure. The data were entered in a Microsoft Excel sheet and analyzed using Statistical Package for Social Science (SPSS) software version 20.

Results: Our findings demonstrate a significant inverse correlation between serum vitamin D levels and MDA (r = -0.71, p < 0.001), indicating lower lipid peroxidation with higher vitamin D levels. Our study concludes by evident higher serum vitamin D levels associated with reduced oxidative stress, reflected by lower MDA.

Conclusion: These findings suggest a potential protective role of vitamin D against oxidative damage, which could have implications for the prevention of oxidative stress-related diseases.

Keywords: blood pressure; malondialdehyde; oxidative stress; reactive oxygen species; vitamin d.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethical Committee of BLDE (Deemed to be University) issued approval IEC/No-09/2021 Dated 22/01/2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Correlation of MAP with MDA
r, correlation coefficient; p ≤ 0.05 is considered as statistically significant; MDA, malondialdehyde; MAP, mean arterial pressure. The Spearman's correlation was performed to get the values.
See this image and copyright information in PMC

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