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Review
. 2024 Sep 11:12:1474711.
doi: 10.3389/fbioe.2024.1474711. eCollection 2024.

Prussian blue nanotechnology in the treatment of spinal cord injury: application and challenges

XiaoPeng Gu #  1   2   3   4 , SongOu Zhang #  1 , WeiHu Ma  2
Affiliations
Review

Prussian blue nanotechnology in the treatment of spinal cord injury: application and challenges

XiaoPeng Gu et al. Front Bioeng Biotechnol. .

Abstract

Spinal cord injury (SCI) is a serious neurological condition that currently lacks effective treatments, placing a heavy burden on both patients and society. Prussian blue nanoparticles exhibit great potential for treating spinal cord injuries due to their excellent physicochemical properties and biocompatibility. These nanoparticles have strong anti-inflammatory and antioxidant capabilities, effectively scavenge free radicals, and reduce oxidative stress damage to cells. Prussian blue nanotechnology shows broad application potential in drug delivery, bioimaging, cancer therapy, anti-inflammatory and oxidative stress treatment, and biosensors. This article reviewed the potential applications of Prussian blue nanotechnology in treating spinal cord injuries, explored the challenges and solutions associated with its application, and discussed the future prospects of this technology in SCI treatment.

Keywords: Prussian blue nanotechnology; inflammation; oxidative stress; spinal cord injury; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Pathology and treatment of SCI acute and subacute phases.
FIGURE 2
FIGURE 2
Characteristics and medical applications of Prussian blue nanoparticles.
FIGURE 3
FIGURE 3
The application of Prussian blue in SCI treatment.
See this image and copyright information in PMC

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References

    1. Ahuja C. S., Wilson J. R., Nori S., Kotter M. R. N., Druschel C., Curt A., et al. (2017). Traumatic spinal cord injury. Nat. Rev. Dis. Prim. 3 (Apr 27), 17018. 10.1038/nrdp.2017.18 - DOI - PubMed
    1. An J., Jiang X., Wang Z., Li Y., Zou Z., Wu Q. (2022). Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. Int. J. Pharm. 628 (Nov 25), 122285. 10.1016/j.ijpharm.2022.122285 - DOI - PubMed
    1. Anjum A., Yazid M. D., Fauzi Daud M., Idris J., Ng A. M. H., Selvi Naicker A., et al. (2020). Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int. J. Mol. Sci. 21 (20), 7533. 10.3390/ijms21207533 - DOI - PMC - PubMed
    1. Bai H., Kong F., Feng K., Zhang X., Dong H., Liu D., et al. (2021a). Prussian blue nanozymes prevent anthracycline-induced liver injury by attenuating oxidative stress and regulating inflammation. ACS Appl. Mater Interfaces 13 (36), 42382–42395. 10.1021/acsami.1c09838 - DOI - PubMed
    1. Bai H., Sun Q., Kong F., Dong H., Ma M., Liu F., et al. (2021b). Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia. J. Mater Chem. B 9 (26), 5245–5254. 10.1039/d1tb00548k - DOI - PubMed

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