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Review
. 2024 Sep 11:18:1475234.
doi: 10.3389/fnint.2024.1475234. eCollection 2024.

Intermittent hypoxic training - derived exosomes in stroke rehabilitation

Myoung-Gwi Ryou  1 , Summer Burton  1
Affiliations
Review

Intermittent hypoxic training - derived exosomes in stroke rehabilitation

Myoung-Gwi Ryou et al. Front Integr Neurosci. .

Abstract

Ischemic stroke is the fourth leading cause of adult disability in the US, and it is a huge social burden all over the world. However, the efficient treatment of ischemic stroke is not available. An apparent reason for failing to find or develop an intervention for ischemic stroke is contributed to the tight blood-brain barrier (BBB). The unique characteristics of exosomes that can traverse BBB have been highlighted among researchers investigating interventions for ischemic stroke conditions. Additionally, intermittent hypoxic training has been considered a potential intervention in the treatment or rehabilitation process of ischemic stroke patients. In this mini-review, we are going to review the possibility of applying exosomes produced by a subject who does intermittent hypoxic conditioning in a treatment program for ischemic stroke.

Keywords: Neuroprotection; exosome; hypoxia; intermittent hypoxic training (IHT); microglia; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Schematic of the biogenesis of the exosome. Where, Endosomal-sorting complex required for transport (ESCRT); Multivesicular body (MVB).
See this image and copyright information in PMC

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