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. 2024 Sep 11:12:1451737.
doi: 10.3389/fpubh.2024.1451737. eCollection 2024.

The association between accelerated biological aging and the risk of osteoarthritis: a cross-sectional study

Qiang He #  1 , Hua Luo #  2 , Jie Mei #  1 , Zhen Wang  3 , Xin Sun  4 , Ling Wang  5 , Chengxin Xie  2   6
Affiliations

The association between accelerated biological aging and the risk of osteoarthritis: a cross-sectional study

Qiang He et al. Front Public Health. .

Abstract

Background: Biological age (BA) offers an effective assessment of true aging state. The progression of Osteoarthritis (OA) is closely associated with an increase in chronological age, the correlation between BA and OA has not been fully elucidated.

Methods: This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Thirteen commonly used clinical traits were employed to calculate two measures of BA: the Klemera-Doubal method age (KDM-Age) and phenotypic age (Pheno-Age). The residuals of the regression of these ages based on chronological age were calculated as KDM-Age or Pheno-Age acceleration, respectively. OA was determined through self-reported prior diagnoses. The prevalence of OA across different quartiles of BA was compared using weighted chi-square tests and linear trend tests. The association between BA and OA was assessed using weighted multivariate logistic regression models.

Results: A total of 30,547 participants aged ≥20 years were included in this study, 3,922 (14%) were diagnosed with OA. Participants with OA exhibited higher chronological age, KDM-Age, Pheno-Age, KDM-Age advance, and Pheno-Age advance compared to those without OA (p < 0.001). The prevalence of OA significantly increased with higher quartiles of KDM-Age advance and Pheno-Age advance (P for trend < 0.001). In the fully adjusted model, compared to the lowest quartile (Q1) of KDM-Age advance, the highest quartile (Q4) was associated with a 36.3% increased risk of OA (OR = 1.363; 95% CI = 1.213 to 1.532, p < 0.001). The highest quartile of Pheno-Age advance (Q4) was associated with a 24.3% increased risk of OA compared to Q1 (OR = 1.243; 95% CI = 1.113 to 1.389, p < 0.001). In males and young people, no statistical differences were found in OA risk between the highest and the lowest quartiles of KDM-Age advance (p = 0.151) and Pheno-Age advance (p = 0.057), respectively.

Conclusion: Adults with accelerated biological aging have an increased risk of OA, particularly among females and older adults.

Keywords: NHANES; biological age; cross-sectional study; epidemiology; osteoarthritis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of population screening.
Figure 2
Figure 2
Weighted number of participants with OA.
Figure 3
Figure 3
Forest plot of the association between BA and risk of OA.
Figure 4
Figure 4
Comparison of BA advance in participants with and without OA. (A) KDM-Age advance. (B) Pheno-Age advance.
See this image and copyright information in PMC

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