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. 2024 Oct 1;4(10):2714-2723.
doi: 10.1158/2767-9764.CRC-24-0257.

DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants

Christopher S Semancik  1 , Naisi Zhao  1 , Devin C Koestler  2   3 , Eric Boerwinkle  4   5 , Jan Bressler  4 , Rachel J Buchsbaum  6 , Karl T Kelsey  7   8 , Elizabeth A Platz  9   10 , Dominique S Michaud  1   7
Affiliations

DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants

Christopher S Semancik et al. Cancer Res Commun. .

Abstract

This study describes associations between immune cell types and cancer risk in a Black population; elevated regulatory T-cell proportions that were associated with increased overall cancer and lung cancer risk, and elevated memory B-cell proportions that were associated with increased prostate and all cancer risk.

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Conflict of interest statement

C.S. Semancik reports grants from Jennifer M. Bjercke Scholar Award Fund for Breast Cancer Research at the Tufts Medical Center during the conduct of the study. E. Boerwinkle reports grants from NIH during the conduct of the study. J. Bressler reports grants from NIH/NHLBI during the conduct of the study. R.J. Buchsbaum reports grants and other from Jennifer M. Bjercke Scholar Award during the conduct of the study, grants from NIH/NHLBI 1R01CA243542 and NIH/NHLBI 1R01HL166810 outside the submitted work, as well as a patent number 11932650 issued. K.T. Kelsey reports a patent number 10,619,211 issued as well as being founder and scientific advisor for Cellintec outside the submitted work. E.A. Platz reports grants from National Cancer Institute during the conduct of the study, personal fees from the American Association for Cancer Research (AACR) outside the submitted work, as well as being an elected member of the AACR Board of Directors. D.S. Michaud reports grants from Jennifer M. Bjercke Scholar Award Fund for Breast Cancer Research at the Tufts Medical Center during the conduct of the study. No disclosures were reported by the other authors.

Figures

Figure 1
Figure 1
All cancer spline plot. The spline plot assesses the change in the HRs at various proportions of Treg cells in all cancers.
Figure 2
Figure 2
Lung cancer spline plot. The spline plot assesses the change in the HRs at various proportions of Treg cells in lung cancer.
See this image and copyright information in PMC

Update of

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