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Review
. 2024;15(10):801-818.
doi: 10.1080/20415990.2024.2389032. Epub 2024 Sep 26.

Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear

Thomas Foster  1   2 , Patrick Lim  1 , Corina Mihaela Ionescu  1 , Susbin Raj Wagle  1 , Bozica Kovacevic  1 , Armin Mooranian  1   3 , Hani Al-Salami  1   4
Affiliations
Review

Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear

Thomas Foster et al. Ther Deliv. 2024.

Abstract

Hearing loss places a significant burden on our aging population. However, there has only been limited progress in developing therapeutic techniques to effectively mediate this condition. This review will outline several of the most commonly utilized practices for the treatment of sensorineural hearing loss before exploring more novel techniques currently being investigated via both in vitro and in vivo research. This review will place particular emphasis on novel gene-delivery technologies. Primarily, it will focus on techniques used to deliver genes that have been shown to encourage the proliferation and differentiation of sensory cells within the inner ear and how these technologies may be translated into providing clinically useful results for patients.

Keywords: bile acids; gene delivery; hearing loss; nanotechnology; stem cells.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

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