Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024;15(10):801-818.
doi: 10.1080/20415990.2024.2389032. Epub 2024 Sep 26.

Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear

Thomas Foster  1   2 , Patrick Lim  1 , Corina Mihaela Ionescu  1 , Susbin Raj Wagle  1 , Bozica Kovacevic  1 , Armin Mooranian  1   3 , Hani Al-Salami  1   4
Affiliations
Review

Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear

Thomas Foster et al. Ther Deliv. 2024.

Abstract

Hearing loss places a significant burden on our aging population. However, there has only been limited progress in developing therapeutic techniques to effectively mediate this condition. This review will outline several of the most commonly utilized practices for the treatment of sensorineural hearing loss before exploring more novel techniques currently being investigated via both in vitro and in vivo research. This review will place particular emphasis on novel gene-delivery technologies. Primarily, it will focus on techniques used to deliver genes that have been shown to encourage the proliferation and differentiation of sensory cells within the inner ear and how these technologies may be translated into providing clinically useful results for patients.

Keywords: bile acids; gene delivery; hearing loss; nanotechnology; stem cells.

Plain language summary

[Box: see text].

PubMed Disclaimer

Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Figures

Figure 1.
Figure 1.
Classifications of hearing loss. A brief summary of some of the causative agents associated with hearing loss.
Figure 2.
Figure 2.
Examples of nanotechnology and gene delivery vectors discussed in this review. A pictorial summary of the nanotechnologies discussed in this review, with particular focus on nonviral delivery techniques for plasmids to the inner ear.
See this image and copyright information in PMC

References

    1. Kiely KM, Anstey KJ. Putting age-related hearing loss on the public health agenda in Australia. Public Health Res Practice. 2021;31(5):3152125. doi: 10.17061/phrp3152125 - DOI - PubMed
    1. McDaid D, Park A-L, Chadha S. Estimating the global costs of hearing loss. Int J Audiol. 2021;60(3):162–170. doi: 10.1080/14992027.2021.1883197 - DOI - PubMed
    1. Cheslock M, De Jesus O. Presbycusis. FL, USA: StatPearls [Internet]: StatPearls Publishing; 2021.
    1. Ryan AF, Harris JP, Keithley EM. Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Oto-Laryngologica. 2002;122(5):38–43. doi: 10.1080/00016480260094965 - DOI - PubMed
    1. Ding T, Yan A, Liu K. What is noise-induced hearing loss? Br J Hosp Med. 2019;80(9):525–529. doi: 10.12968/hmed.2019.80.9.525 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources