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. 2024 Nov 6;68(11):e0075224.
doi: 10.1128/aac.00752-24. Epub 2024 Sep 26.

Impact of obesity on clinical outcomes of methicillin-susceptible Staphylococcus aureus bloodstream infections

Anthony S Wasielewski  1 , Anthony M Casapao  2 , Christopher A Jankowski  1 , Carmen L Isache  3 , Malleswari Ravi  4 , Ashlan J Kunz Coyne  1
Affiliations

Impact of obesity on clinical outcomes of methicillin-susceptible Staphylococcus aureus bloodstream infections

Anthony S Wasielewski et al. Antimicrob Agents Chemother. .

Abstract

Obesity affects over one-third of U.S. adults and complicates the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). A study at the University of Florida Health Centers compared clinical outcomes between 233 obese and non-obese patients receiving cefazolin for MSSA BSI. No significant differences were found in clinical success (81.9% vs 82.7%), mortality (7.2% vs 5.3%), or adverse events (3.6% vs 3.3%). However, obese patients took longer to clear blood cultures (4.62 vs 4.01 days, P = 0.017).

Keywords: cefazolin; methicillin-susceptible Staphylococcus aureus; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

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