Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Oct 1;30(7S Suppl 1):S49-S55.
doi: 10.1097/RHU.0000000000002128.

Reproductive Health in Scleroderma, Vasculitis, and Sjögren Syndrome

Francesca Crisafulli  1 , Maria Grazia Lazzaroni  1 , Cecilia Nalli  1 , Rossana Orabona  2 , Franco Franceschini  1 , Angela Tincani  1
Affiliations
Review

Reproductive Health in Scleroderma, Vasculitis, and Sjögren Syndrome

Francesca Crisafulli et al. J Clin Rheumatol. .

Abstract

Women with systemic chronic inflammatory disease, such as those with scleroderma, systemic vasculitis, and Sjögren syndrome, need preconception evaluation by a multidisciplinary team. Counseling and pregnancy management should be tailored to patients' needs, considering specific disease features, organ involvement, treatment options, and risk factors to minimize risks of maternal-fetal complications during pregnancy.Additionally, considerations regarding fertility, assisted reproductive techniques, and contraception also need to be addressed for these women.In this narrative review, we integrate the current published literature with our expert opinion to address the issues faced by patients with the aforementioned inflammatory conditions.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE
FIGURE
Risk stratification for pregnancy in patients with systemic sclerosis, systemic vasculitis, and Sjögren syndrome. A, Risk factors of rheumatological competence. B, Risk factors of obstetrical competence. C, Risk factors usually investigated by both specialists' groups. This picture underlines the importance of a multidisciplinary prepregnancy counseling.
See this image and copyright information in PMC

References

    1. Siegel CH, Sammaritano LR. Safety of Medications Used to treat Autoimmune Rheumatic Diseases During Pregnancy and Lactation. J Clin Rheumatol. 2024;30:S25–S34. - PubMed
    1. Allanore Y Simms R Distler O, et al. . Systemic sclerosis. Nat Rev Dis Primers. 2015;1:15002. - PubMed
    1. Lazzaroni MG Crisafulli F Moschetti L, et al. . Reproductive issues and pregnancy implications in systemic sclerosis. Clin Rev Allergy Immunol. 2023;64:321–342. - PubMed
    1. Sampaio-Barros PD, Samara AM, Marques Neto JF. Gynaecologic history in systemic sclerosis. Clin Rheumatol. 2000;19:184–187. - PubMed
    1. Steen VD, Medsger TA. Fertility and pregnancy outcome in women with systemic sclerosis. Arthritis Rheum. 1999;42:763–768. - PubMed

MeSH terms