Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;202(6):801-807.
doi: 10.1007/s00408-024-00750-x. Epub 2024 Sep 26.

Tidal Breathing Analysis as a Prognostic Index for Airway Obstruction Trajectory and Asthma in Preterm Infants

Yoon Hee Kim  1   2 , Mireu Park  2   3 , Soo Yeon Kim  2   3 , Yun Young Roh  1   2 , Jong Deok Kim  2   3 , Min Jung Kim  2   4 , Yong Ju Lee  2   4 , Kyung Won Kim  2   3 , Myung Hyun Sohn  5   6
Affiliations

Tidal Breathing Analysis as a Prognostic Index for Airway Obstruction Trajectory and Asthma in Preterm Infants

Yoon Hee Kim et al. Lung. 2024 Dec.

Abstract

Introduction: An easy-to-implement and accurate lung function assessment tool for preterm infants is crucial to manage lifelong respiratory morbidities. We aimed to determine which pulmonary function parameters in preterm infants can predict the trajectory of airway obstruction and asthma development after 4 years of age.

Methods: We evaluated 52 preterm infants who had undergone both tidal breathing flow-volume loop (TBFVL) and multiple-breath washout (MBW) analyses in infancy and spirometry after the age of 4 years. We evaluated the association between pulmonary function parameters in infancy and childhood and the pulmonary function trajectory until 13 years of age and compared the changes in this trajectory according to pulmonary function parameters in infancy.

Results: Time to peak expiratory flow/expiratory time (TPEF/TE) in infancy was associated with FEV1, FEF25-75, and dysanapsis ratio in childhood and differed according to level of airway obstruction assessed by FEV1, FEV1/FVC, and FEF25-75, an asthma development. TPEF/TE was a significant predictive factor for airway obstruction and asthma after 4 years of age, after adjusting for sex, extreme prematurity, duration of supplementary oxygen and mechanical ventilation, and recurrent wheezing during infancy. In premature infants with lower TPEF/TE, subsequent pulmonary function parameters remained low until 13 years of age.

Conclusion: In preterm infants, TPEF/TE could be useful to predict airway obstruction and asthma after 4 years of age and even a lower pulmonary function trajectory until 13 years of age. This information may help clinicians to provide lifelong care for pulmonary morbidity in children and adolescents born preterm.

Keywords: Airway obstruction; Asthma; Bronchopulmonary dysplasia; Infant pulmonary function; Premature.

PubMed Disclaimer

References

    1. D’Agata AL, Green CE, Sullivan MC (2009) A new patient population for adult clinicians: preterm born adults. Lancet Reg Health Am 9:100188. https://doi.org/10.1016/j.lana.2022.100188 - DOI
    1. Kelly MM, Tobias J, Griffith PB (2021) Addressing preterm birth history with clinical practice recommendations across the life course. J Pediatr Health Care 35:e5–e20. https://doi.org/10.1016/j.pedhc.2020.12.008 - DOI - PubMed
    1. Carregã M, Sousa P, Rocha G, Ferreira-Magalhães M, Azevedo I (2023) Respiratory and non-respiratory outcomes of bronchopulmonary dysplasia in adolescents: a systematic review. Early Hum Dev 180:105756. https://doi.org/10.1016/j.earlhumdev.2023.105756 - DOI - PubMed
    1. Collaco JM, McGrath-Morrow SA (2021) Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life. Pediatr Pulmonol 56:3464–3471. https://doi.org/10.1002/ppul.25301 - DOI - PubMed - PMC
    1. Simpson SJ, Hall GL, Wilson AC (2015) Lung function following very preterm birth in the era of “new” bronchopulmonary dysplasia. Respirology 20:535–540. https://doi.org/10.1111/resp.12503 - DOI - PubMed

Publication types

MeSH terms