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. 2024 Oct 22;43(10):114816.
doi: 10.1016/j.celrep.2024.114816. Epub 2024 Sep 25.

Destruction as a creative process: CAD-induced DNA strand breaks promote macrophage differentiation

Dalal Alsowaida  1 , Lynn A Megeney  2
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Destruction as a creative process: CAD-induced DNA strand breaks promote macrophage differentiation

Dalal Alsowaida et al. Cell Rep. .
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Abstract

In a recent issue of Cell Reports, Maurya et al.1 demonstrated that Drep4, the Drosophila homolog of caspase-activated DNase (CAD), drives DNA strand breaks during myeloid-like/macrophage cell differentiation and that this Drep4/CAD activity is essential for the differentiation process.

Keywords: CP: Immunology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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