Serum dsDNA is environmentally contingent

Qi Zhen¹, Weiwei Chen¹, Yang Han¹, Yirui Wang², Zhuo Li², Guangbo Qu³, Huiyao Ge², Bao Li⁴, Yiwen Mao², Yafen Yu², Bingxue Bai⁵, Chengzhi Lv⁶, Jin Zhang⁷, Huaqing Hu⁸, Qijun Jiang⁹, Xiaojing Kang¹⁰, Yuanhong Xu¹¹, Yan Lu¹², Juan Zhao¹³, Song Wu¹⁴, Shijie Li¹⁵, Xia Chen¹⁶, Ruiqun Qi¹⁶, Xiaohong Lin¹⁷, Jianwen Han¹⁸, Yonghong Lu¹⁵, Jihai Shi¹⁹, Ying Qiu²⁰, Yiming Fan¹⁴, Shanshan Li²¹, Fuqiu Li²², Yuzhen Li⁵, XingHua Gao¹⁶, Liangdan Sun²³

Affiliations

¹ North China University of Science and Technology Affiliated Hospital, Thangshan 063000, China; Inflammation and Immune Diseases Laboratory of North China University of Science and Technology, Tangshan 063210, China; Health Science Center, North China University of Science and Technology, Tangshan 063210, China; Key Laboratory for quality of salt alkali resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, 063210, China.
² Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China.
³ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
⁴ Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; The Comprehensive Lab, College of Basic, Anhui Medical University, Hefei 230032, China.
⁵ Department of Dermatology at No.2 Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China.
⁶ Dalian Dermatosis Hospital, Dalian, Liaoning 116021, China.
⁷ Wuhan Special Service Recuperation Center, Wuhan 430010, China.
⁸ Health Management Center, No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
⁹ Donggang Center Hospital, Dandong, Liaoning 118300, China.
¹⁰ Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi 830001, China.
¹¹ Department of Clinical Laboratory at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
¹² Dermatology Department of the First Affiliated Hospital, Nanjng Medical University, Nanjing, Jiangsu 210029, China.
¹³ Urology Institute of Shenzhen University, the Luohu Affiliated Hospital of Shenzhen University, Youyi Road, Luohu District, Shenzhen, 518000, China.
¹⁴ Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524013, China.
¹⁵ Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu 610017, China.
¹⁶ Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning 110001, China.
¹⁷ Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China.
¹⁸ Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, China.
¹⁹ Dermatology at the First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014030, China.
²⁰ Department of Dermatology, Jining No. 1 People's Hospital, Shandong 272011, China.
²¹ Department of Dermatology at No.1 Hospital of Jilin University, Changchun, Jilin 130021, China.
²² Department of Dermatology, the Second Hospital of Jilin University, Changchun 130041, China.
²³ North China University of Science and Technology Affiliated Hospital, Thangshan 063000, China; Inflammation and Immune Diseases Laboratory of North China University of Science and Technology, Tangshan 063210, China; Health Science Center, North China University of Science and Technology, Tangshan 063210, China; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China; School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China; Key Laboratory for quality of salt alkali resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, 063210, China. Electronic address: ahmusld@163.com.

PMID: 39326294
DOI: 10.1016/j.intimp.2024.113215

Serum dsDNA is environmentally contingent

Qi Zhen et al. Int Immunopharmacol. 2024.

. 2024 Dec 5;142(Pt B):113215.

doi: 10.1016/j.intimp.2024.113215. Epub 2024 Sep 25.

Authors

Affiliations

¹ North China University of Science and Technology Affiliated Hospital, Thangshan 063000, China; Inflammation and Immune Diseases Laboratory of North China University of Science and Technology, Tangshan 063210, China; Health Science Center, North China University of Science and Technology, Tangshan 063210, China; Key Laboratory for quality of salt alkali resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, 063210, China.
² Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China.
³ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
⁴ Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; The Comprehensive Lab, College of Basic, Anhui Medical University, Hefei 230032, China.
⁵ Department of Dermatology at No.2 Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China.
⁶ Dalian Dermatosis Hospital, Dalian, Liaoning 116021, China.
⁷ Wuhan Special Service Recuperation Center, Wuhan 430010, China.
⁸ Health Management Center, No.1 Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
⁹ Donggang Center Hospital, Dandong, Liaoning 118300, China.
¹⁰ Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi 830001, China.
¹¹ Department of Clinical Laboratory at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
¹² Dermatology Department of the First Affiliated Hospital, Nanjng Medical University, Nanjing, Jiangsu 210029, China.
¹³ Urology Institute of Shenzhen University, the Luohu Affiliated Hospital of Shenzhen University, Youyi Road, Luohu District, Shenzhen, 518000, China.
¹⁴ Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524013, China.
¹⁵ Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu 610017, China.
¹⁶ Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning 110001, China.
¹⁷ Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China.
¹⁸ Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, China.
¹⁹ Dermatology at the First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014030, China.
²⁰ Department of Dermatology, Jining No. 1 People's Hospital, Shandong 272011, China.
²¹ Department of Dermatology at No.1 Hospital of Jilin University, Changchun, Jilin 130021, China.
²² Department of Dermatology, the Second Hospital of Jilin University, Changchun 130041, China.
²³ North China University of Science and Technology Affiliated Hospital, Thangshan 063000, China; Inflammation and Immune Diseases Laboratory of North China University of Science and Technology, Tangshan 063210, China; Health Science Center, North China University of Science and Technology, Tangshan 063210, China; Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China; School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China; Key Laboratory for quality of salt alkali resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, 063210, China. Electronic address: ahmusld@163.com.

PMID: 39326294
DOI: 10.1016/j.intimp.2024.113215

Abstract

Psoriasis is a recurrent autoimmune disease characterized by seasonal and latitudinal variations. Double-stranded DNA (dsDNA) is a crucial component of nucleic acids and nucleosomes that provoke innate immune responses. Given the potential influence of climate on immunity and the development of autoimmune diseases, a comprehensive quantitative analysis of dsDNA levels in the population is warranted. In this case-control study conducted from 2016 to 2020, 10,110 psoriasis patients and matched controls from 12 regions in China were included. This study examined variations in serum dsDNA levels based on season and latitude. The results revealed significant associations between geographical location, climatic conditions, and season with serum dsDNA concentration. Individuals residing in Northern China exhibited significantly higher serum dsDNA levels compared to those in the South (1.00 vs. 0.96 ng/ml), and those in medium latitude regions had higher levels than their counterparts in areas with extreme latitudes (0.98 vs. 0.96 ng/ml). Furthermore, individuals in regions with low to medium ultraviolet exposure demonstrated higher serum dsDNA concentrations than those in areas with high ultraviolet levels (1.03 vs. 0.93 ng/ml), and individuals in winter showed higher levels than those in summer (1.03 vs. 0.92 ng/ml). Factors such as sex, UV index, humidity, and sunshine duration were inversely related to serum dsDNA levels, while age and daylight hours showed a positive association. These findings suggest that meteorological and climatic factors play a role in influencing serum dsDNA levels.

Keywords: Autoimmune disease; Double-stranded DNA; Environment; Psoriasis.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Serum dsDNA is environmentally contingent

Affiliations

Serum dsDNA is environmentally contingent

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical