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Review
. 2025 Jan-Feb;70(1):132-140.
doi: 10.1016/j.survophthal.2024.09.007. Epub 2024 Sep 24.

Corneal densitometry: A new evaluation indicator for corneal diseases

Affiliations
Review

Corneal densitometry: A new evaluation indicator for corneal diseases

Qing Yang et al. Surv Ophthalmol. 2025 Jan-Feb.

Abstract

Corneal densitometry (CD) uses the biological properties of the cornea to visualize the morphology of the cornea and determine the degree of corneal transparency. At present, it is an emerging metric that has shown promise in various clinical diagnosis and evaluation of eye diseases and surgeries. We introduce the different methodologies used to measure CD. Furthermore, we systematically categorize the diagnostic value of CD into high, medium, and low levels based on its clinical significance. By analyzing a wide range of conditions, including keratoconus, postrefractive surgery changes, and other corneal pathologies, we assess the utility of CD in each context. We also discuss the potential implications of these classifications for disease monitoring and prognosis evaluation. Our review underscores the importance of integrating CD assessments into routine clinical practice to enhance the accuracy and effectiveness of diagnostic processes for corneal disorders.

Keywords: Backscatter; Clinical application; Corneal densitometry; Corneal transparency.

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Conflict of interest statement

Declaration of Competing Interest The authors have no relevant financial or non-financial interests to disclose.

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