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Meta-Analysis
. 2024 Dec;31(12):986-1003.
doi: 10.1016/j.jmig.2024.09.020. Epub 2024 Sep 24.

Urodynamic Profile and Impact of Surgery in Women Affected by Deep Infiltrating Endometriosis: A Systematic Review and Meta-Analysis

Alessandro Ferdinando Ruffolo  1 , Carolina Dolci  2 , Chrystele Rubod  3 , Massimo Candiani  2 , Stefano Salvatore  2 , Marine Lallemant  3 , Michel Cosson  3
Affiliations
Meta-Analysis

Urodynamic Profile and Impact of Surgery in Women Affected by Deep Infiltrating Endometriosis: A Systematic Review and Meta-Analysis

Alessandro Ferdinando Ruffolo et al. J Minim Invasive Gynecol. 2024 Dec.

Abstract

Objective: To evaluate the impact of deep infiltrating endometriosis (DIE) on bladder function and the possible impact of surgical resection.

Data sources: A systematic literature research was performed using the PubMed/MEDLINE and EMBASE database (last search date: April 30, 2024).

Methods of study selection: We included studies that evaluated the urodynamics (UDS) findings in women affected by DIE before submission to surgery. Following epidemiological designs were considered suitable: randomized control trials, observational prospective or retrospective studies, and case series. Metanalysis was performed using Jamovi Software version 2.3.28 (Sydney, Australia), according to PRISMA 2020 guidelines. Nine publications were included.

Tabulation, integration, and results: Nine studies, including 574 women affected by DIE and submitted to urodynamic assessment, were included. In women affected by DIE, preoperative detrusor overactivity (DO) was reported in 15% (95% confidence interval [CI] 3, 26; I2 = 93.9%, p <.001), preoperative voiding dysfunction in 21% (95% CI 12, 29; I2 = 78.1%, p <.001) and preoperative low maximum cystometry capacity was shown in 18% (95% CI -2, 38; I2 = 97.2%, p <.001). An abnormal bladder sensation was recorded in 39% of patients (95% CI 18, 60; I2 = 86%, p <.001), low preoperative bladder compliance was reported in 35% of patients (95% CI 30, 40; I2 = 0%, p = .66) and preoperative painful bladder filling was showed in 37% of the evaluated population (95% CI 27, 48; I2 = 0%, p = .58). No difference between preoperative and postoperative UDS detrusor overactivity was reported (odds ratio [OR] 0.45; 95% CI -0.10, 1.0, I2 = 0%; p = .66). Moreover, no difference in preoperative and postoperative voiding dysfunction was reported (OR 0.0; 95% CI -0.76, 0.76, I2 = 49.6%; p = .12).

Conclusion: Abnormal urodynamic findings before surgery are prevalent in women with DIE. Surgery seems not to affect UDS outcomes in women affected by DIE. However, heterogeneity among included studies may limit the generalizability of our findings.

Keywords: Deep infiltrating endometriosis; Endometriosis; Lower urinary tract symptoms; Urodynamics.

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