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Meta-Analysis
. 2024 Nov;310(5):2577-2585.
doi: 10.1007/s00404-024-07748-z. Epub 2024 Sep 26.

Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers-a meta-analysis

Azharuddin Sajid Syed Khaja  1 , Mohd Saleem  2 , Mubashir Zafar  3 , Soha Moursi  2 , Ghorashy Eltayeb Yousif Mohammed  2 , Syed Monowar Alam Shahid  4 , Sahar Hammam  5 , Safia Moussa  6 , Mohammed Salem Alharbi  7 , Ahmed Nawi Alshammari  7
Affiliations
Meta-Analysis

Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers-a meta-analysis

Azharuddin Sajid Syed Khaja et al. Arch Gynecol Obstet. 2024 Nov.

Abstract

Background and aim: The present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices.

Methodology: A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I2 statistic.

Results: Our analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033-2.207), uterine cancer (OR = 1.263, 95% CI 0.827-2.143), cervical cancer (OR = 1.000, 95% CI 0.900-1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400-4.000) compared to those without such a history. The overall heterogeneity across studies was high (I2 = 82.92%), suggesting varying trends across different populations and study designs.

Conclusion: This meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.

Keywords: Early detection; Genitourinary cancers; Meta-analysis; Pelvic inflammatory disease; Women’s health.

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References

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