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Review
. 2024 Sep 7;10(18):e37541.
doi: 10.1016/j.heliyon.2024.e37541. eCollection 2024 Sep 30.

Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium

Xin Wei  1   2 , Dan Wang  2   3 , Ziming Xu  2   4 , Jiajia Liu  2   3 , Qizhi Zhu  1   2 , Qi Chen  1   2 , Heng Tang  5 , Weiping Xu  1   2   3   6
Affiliations
Review

Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium

Xin Wei et al. Heliyon. .

Abstract

Dendrobium is a precious Chinese herbal medicine, which belongs to the genus Orchidaceae. Ancient records and modern pharmacological research show that Dendrobium has pharmacological effects such as anti-tumor, antioxidant regulating immunity and blood glucose, and anti-aging. Dendrobium contains polysaccharides, alkaloids, bibenzyl, sesquiterpenes, phenanthrene, polyphenols and other types of chemicals. Its pharmacological activity is closely related to these chemical components. For example, dendrobium extracts can achieve anti-tumor effects by inhibiting tumor cell proliferation and metastasis, promoting cell apoptosis and ferroptosis, or increasing cell sensitivity to chemotherapy drugs. It enhances immunity by regulating immune cell activity or cytokine release. In addition, it can alleviate neurodegenerative diseases by protecting nerve cells from apoptotic damage. In recent years, research reports on biologically active compounds in Dendrobium have shown a blowout growth, which makes us realize that it is meaningful to continuously update the research progress on the components and pharmacological regulatory mechanism of this traditional Chinese medicine. By classifying the collected chemical components according to different chemical structures and summarizing their pharmacological mechanisms, we investigated the current research progress of Dendrobium and provide a more comprehensive scientific foundation for the further development and clinical transformation of Dendrobium in the future.

Keywords: Chemical composition; Dendrobium; Dendrobium polysaccharides; Pharmacological mechanism.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Schematic diagram of the effect of the traditional Chinese medicine Dendrobium on the human body (created with BioRender).
Fig. 2
Fig. 2
The main compound types obtained by separation and extraction of Dendrobium (created with BioRender).
Fig. 3
Fig. 3
Related pathways of Dendrobium polysaccharides regulating cellular biological processes (created with BioRender).
See this image and copyright information in PMC

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