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Clinical Trial
. 1979;8(Suppl 2):149S-151S.

A comparative study of methyldopa and labetalol in the treatment of hypertension

G L Sanders, D M Davies, G M Gales, J G Rao, M D Rawlins, P A Routledge
Clinical Trial

A comparative study of methyldopa and labetalol in the treatment of hypertension

G L Sanders et al. Br J Clin Pharmacol. 1979.

Abstract

1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic) were reduced by 29/14 mmHg with methyldopa and by 29/15 mmHg with labetalol. 4 Both lying and standing heart rates were reduced with labetalol. 5 It is concluded that the antihypertensive properties of labetalol and methyldopa are similar but that larger patient populations are needed to study the relative incidence of subjective adverse effects.

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References

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