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Review
. 2024 Aug 26;16(8):e67856.
doi: 10.7759/cureus.67856. eCollection 2024 Aug.

Approaches in Adult Glioblastoma Treatment: A Systematic Review of Emerging Therapies

Billy McBenedict  1 , Wilhelmina N Hauwanga  2 , Anna Pogodina  3 , Gurinder Singh  4 , Anusha Thomas  5 , Abdullah Mohammed Abdullah Ibrahim  6 , Chukwuwike Johnny  7 , Bruno Lima Pessôa  1
Affiliations
Review

Approaches in Adult Glioblastoma Treatment: A Systematic Review of Emerging Therapies

Billy McBenedict et al. Cureus. .

Abstract

Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults, characterized by complex genetic changes and a poor prognosis. Current standard therapies, including surgery, chemotherapy, and radiotherapy, have limited effectiveness. Emerging therapeutic strategies aim to address the high recurrence rate and improve outcomes by targeting glioblastoma stem cells (GSCs), the blood-brain barrier, and utilizing advanced drug delivery systems. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. An electronic search was conducted across several databases, including PubMed, Embase, Scopus, Web of Science, and Cochrane, covering studies published from January 2019 to May 2024. The inclusion criteria encompassed primary research studies in English focusing on emerging therapies for treating GB in adults. Eligible studies included experimental and observational studies. Only peer-reviewed journal articles were considered. Exclusion criteria included non-human studies, pediatric studies, non-peer-reviewed articles, systematic reviews, case reports, conference abstracts, and editorials. The search identified 755 articles and, finally, 24 of them met the inclusion criteria. The key findings highlight various promising therapies. Despite advances in treatment approaches, the complexity and heterogeneity of GB necessitate ongoing research to optimize these innovative strategies. The study has limitations that should be considered. The inclusion of only English-language articles may introduce language bias, and the focus on peer-reviewed articles could exclude valuable data from non-peer-reviewed sources. Heterogeneity among studies, particularly in sample sizes and designs, complicates comparison and synthesis, while the reliance on preclinical models limits generalizability to clinical practice. Nonetheless, this review provides a comprehensive overview of the emerging therapies that hold promise for improving patient outcomes in GB treatment.

Keywords: blood-brain barrier; drug delivery systems; emerging therapies; glioblastoma; immunotherapy.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram indicating the steps taken to filter the articles for this review
See this image and copyright information in PMC

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References

    1. Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer. Gimple RC, Bhargava S, Dixit D, Rich JN. Genes Dev. 2019;33:591–609. - PMC - PubMed
    1. Glioblastoma multiforme - a look at the past and a glance at the future. King JL, Benhabbour SR. Pharmaceutics. 2021;13:1053. - PMC - PubMed
    1. Epidemiologic and molecular prognostic review of glioblastoma. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL. Cancer Epidemiol Biomarkers Prev. 2014;23:1985–1996. - PMC - PubMed
    1. Viral control of glioblastoma. Mihelson N, McGavern DB. Viruses. 2021;13:1264. - PMC - PubMed
    1. Recent developments in glioblastoma therapy: oncolytic viruses and emerging future strategies. Hamad A, Yusubalieva GM, Baklaushev VP, Chumakov PM, Lipatova AV. Viruses. 2023;15:547. - PMC - PubMed

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