Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 23;9(9):508.
doi: 10.3390/biomimetics9090508.

Development and Evaluation of Fucoidan-Loaded Electrospun Polyvinyl Alcohol/Levan Nanofibers for Wound Dressing Applications

Natavan Ismayilova  1   2 , Muhammad Khaqan Zia  3 , Hatice Selen Akkaya  4 , Songul Ulag  2   5   6 , Yeliz Guldorum  2   7 , Ebru Toksoy Oner  8 , Erol Ince  1 , Liviu Duta  9 , Oguzhan Gunduz  2   5
Affiliations

Development and Evaluation of Fucoidan-Loaded Electrospun Polyvinyl Alcohol/Levan Nanofibers for Wound Dressing Applications

Natavan Ismayilova et al. Biomimetics (Basel). .

Abstract

Wound dressing is an ancient technique for promoting healing, and modern technology has led to the development of advanced dressings that enhance patient care. Nanofiber-based wound dressings are a medical innovation with enhanced properties, including improved adhesion, reduced infection rates, and increased tissue regeneration. This article focuses on electrospun nanofibrous wound dressing materials produced using the widely adopted method of electrospinning. This article explores several parameters that influence fiber size, including electrical conductivity, electric potential, collector distance, viscosity, flow rate, and surface tension. With Fucoidan (FUC) loading, an increase in the fiber diameter of the control group from 310 nm to 395 nm was observed. This research also examines the use of Halomonas Levan (HL), a polysaccharide, and polyvinyl alcohol (PVA) polymer as wound dressing materials to enhance the mechanical properties of the latter. The incorporation of various concentrations of FUC into PVA-HL electrospun nanofibers yielded diverse effects on tensile strength: an enhancement was observed in the PVA-HL-10FUC formulation, while reductions were noted in the PVA-HL-13FUC and PVA-HL-15FUC formulations. The WST1 assay demonstrated that none of the samples exhibited cytotoxicity up to 72 h, as cell viability increased over time. In conclusion, nanofibrous PVA-HL structures loaded with FUC, which promote tissue regeneration and prevent infection, could be considered a novel wound dressing material.

Keywords: Halomonas Levan; electrospinning; fucoidan; polyvinyl alcohol; wound dressing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Scanning electron microscopy images and the corresponding distribution of fiber diameters of electrospun nanofibrous mats: PVA-HL (A–C), PVA-HL-10FUC (D–F), PVA-HL-13FUC (G–I), and PVA-HL-15FUC (J–L).
Figure 2
Figure 2
FTIR spectra of electrospun nanofibrous mats: PVA (a), FUC (b), HL (c), PVA-HL (d), PVA-HL-10FUC (e), PVA-HL-13FUC (f), and PVA-HL-15FUC (g).
Figure 3
Figure 3
DSC graph of electrospun nanofibrous mats: PVA (a), PVA-HL (b), PVA-HL-10FUC (c), PVA-HL-13FUC (d), and PVA-HL-15FUC (e).
Figure 4
Figure 4
Tensile test measurement of nanofibrous electrospun mats: tensile strength (a) and strain at break (b).
Figure 5
Figure 5
Cell viability of control and electrospun nanofibrous mats at 24, 48, and 72 h (* p ≤ 0.5; data calculated as mean ± SD, n = 3).
Figure 6
Figure 6
The linear calibration curve (a) and absorbance graph of FUC (b). The cumulative release behavior of FUC from the PVA-HL nanofibers (c).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Borda L.J., Macquhae F.E., Kirsner R.S. Wound Dressings: A Comprehensive Review. Curr. Dermatol. Rep. 2016;5:287–297. doi: 10.1007/s13671-016-0162-5. - DOI
    1. Ovington L.G. Advances in Wound Dressings. Clin. Dermatol. 2007;25:33–38. doi: 10.1016/j.clindermatol.2006.09.003. - DOI - PubMed
    1. Babalska Z.Ł., Korbecka-Paczkowska M., Karpiński T.M. Wound Antiseptics and European Guidelines for Antiseptic Application in Wound Treatment. Pharmaceuticals. 2021;14:1253. doi: 10.3390/ph14121253. - DOI - PMC - PubMed
    1. Ambekar R.S., Kandasubramanian B. Advancements in Nanofibers for Wound Dressing: A Review. Eur. Polym. J. 2019;117:304–336. doi: 10.1016/j.eurpolymj.2019.05.020. - DOI
    1. Sandri G., Rossi S., Bonferoni M.C., Caramella C., Ferrari F. Therapeutic Dressings and Wound Healing Applications. Wiley Online Library; Hoboken, NJ, USA: 2020. Electrospinning Technologies in Wound Dressing Applications.

LinkOut - more resources