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Review
. 2024 Sep 20;46(9):10444-10461.
doi: 10.3390/cimb46090621.

Hyaluronic Acid in Nanopharmaceuticals: An Overview

Sina Matalqah  1 , Zainab Lafi  1 , Sara Yousef Asha  2
Affiliations
Review

Hyaluronic Acid in Nanopharmaceuticals: An Overview

Sina Matalqah et al. Curr Issues Mol Biol. .

Abstract

Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays a critical role in maintaining skin structure and hydration. Its unique properties make it a valuable component in the field of nanopharmaceuticals. The combination of HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving the delivery and efficacy of drugs. HA-based nanoparticles, including solid lipid nanoparticles, and polymeric nanogels, offer controlled release, enhanced stability, and targeted delivery of therapeutic agents. These innovations significantly improve therapeutic outcomes and reduce side effects, making HA an essential tool in modern medicine. In general, HA-modified liposomes enhance drug encapsulation and targeting, while HA-modified solid lipid nanoparticles (SLNs) provide a solid lipid core for drug encapsulation, offering controlled release and stability. This article provides an overview of the potential applications and recent advancements of HA in nanopharmaceuticals, emphasizing its significant impact on the evolving field of targeted drug delivery and advanced therapeutic strategies. By delving into the unique properties of HA and its compatibility with various therapeutic agents, this review underscores the promising potential of HA in revolutionizing nanopharmaceuticals.

Keywords: hyaluronic acid; lubricant; nanopharmaceuticals; nanotechnology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme for different applications of hyaluronic acid.
Figure 2
Figure 2
Hyaluronic acid’s structure.
Figure 3
Figure 3
Schematic representation of hyaluronic acid synthesis.
Figure 4
Figure 4
Schematic illustration of hyaluronic acid-based nanoparticles, showing their targeted ability through a CD44 receptor.
See this image and copyright information in PMC

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