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Review
. 2024 Sep 18;22(9):424.
doi: 10.3390/md22090424.

Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms

Guihua Yang  1 , Miaoping Lin  1 , Kumaravel Kaliaperumal  2 , Yaqi Lu  1 , Xin Qi  1 , Xiaodong Jiang  1 , Xinya Xu  1 , Chenghai Gao  1 , Yonghong Liu  1 , Xiaowei Luo  1
Affiliations
Review

Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms

Guihua Yang et al. Mar Drugs. .

Abstract

Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties of anti-inflammatory natural products reported from marine microorganisms in the past three years (2021-2023). Approximately 252 anti-inflammatory compounds, including 129 new ones, were predominantly obtained from marine fungi and they are structurally divided into polyketides (51.2%), terpenoids (21.0%), alkaloids (18.7%), amides or peptides (4.8%), and steroids (4.3%). This review will shed light on the development of marine microbial secondary metabolites as potential anti-inflammatory lead compounds with promising clinical applications in human health.

Keywords: anti-inflammatory compounds; chemical structures; marine microorganisms; secondary metabolites; structure–activity relationship.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structures of polyketides (1–18).
Figure 2
Figure 2
Chemical structures of polyketides (19–28).
Figure 3
Figure 3
Chemical structures of polyketides (29–34).
Figure 4
Figure 4
Chemical structures of polyketides (35–48).
Figure 5
Figure 5
Chemical structures of polyketides (49–59).
Figure 6
Figure 6
Chemical structures of polyketides (60–77).
Figure 7
Figure 7
Chemical structures of polyketides (78–95).
Figure 8
Figure 8
Chemical structures of polyketides (96–113).
Figure 9
Figure 9
Chemical structures of polyketides (114–129).
Figure 10
Figure 10
Chemical structures of sesquiterpenoids (130–139).
Figure 11
Figure 11
Chemical structures of sesquiterpenoids and diterpene (140–162).
Figure 12
Figure 12
Chemical structures of triterpenoids (163–177).
Figure 13
Figure 13
Chemical structures of meroterpenoids (178–182).
Figure 14
Figure 14
Chemical structures of alkaloids (183–190).
Figure 15
Figure 15
Chemical structures of alkaloids (191–204).
Figure 16
Figure 16
Chemical structures of alkaloids (205–216).
Figure 17
Figure 17
Chemical structures of alkaloids (217–229).
Figure 18
Figure 18
Chemical structures of amides and peptides (230–241).
Figure 19
Figure 19
Chemical structures of steroids (242–252).
Figure 20
Figure 20
The sources of marine microbial anti-inflammatory natural products (2021–2023).
Figure 21
Figure 21
The habitat distribution of anti-inflammatory natural product-producing marine microorganisms.
Figure 22
Figure 22
Structural types of marine microbial anti-inflammatory natural products (2021–2023).
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References

    1. Almughrbi A.H., Crovella S. Molecular analysis of inflammatory diseases. Exp. Dermatol. 2022;31:9–16. doi: 10.1111/exd.14581. - DOI - PubMed
    1. Deng L.Y., He S.S., Guo N.Q., Tian W., Zhang W.Z., Luo L.X. Molecular mechanisms of ferroptosis and relevance to inflammation. Inflamm. Res. 2022;72:281–299. doi: 10.1007/s00011-022-01672-1. - DOI - PMC - PubMed
    1. Lucido M.J., Bekhbat M., Goldsmith D.R., Treadway M.T., Haroon E., Felger J.C., Miller A.H., Dantzer R. Aiding and abetting anhedonia: Impact of inflammation on the brain and pharmacological implications. Pharmacol. Rev. 2021;73:1084–1117. doi: 10.1124/pharmrev.120.000043. - DOI - PMC - PubMed
    1. Coll R.C., Schroder K., Pelegrín P. NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharmacol. Sci. 2022;43:653–668. doi: 10.1016/j.tips.2022.04.003. - DOI - PubMed
    1. Fu Y., Xiang Y., Li H.L., Chen A.Q., Dong Z. Inflammation in kidney repair: Mechanism and therapeutic potential. Pharmacol. Ther. 2022;237:108240. doi: 10.1016/j.pharmthera.2022.108240. - DOI - PubMed

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