Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2024 Nov:212:114335.
doi: 10.1016/j.ejca.2024.114335. Epub 2024 Sep 21.

Instrumental activities of daily living in neuro-oncology: International validation of the EORTC IADL-BN32 questionnaire

Q Oort  1 , J C Reijneveld  2 , S A M Sikkes  3 , J A F Koekkoek  4 , F Boele  5 , T Young  6 , C Brannan  6 , T Chalk  6 , A Talacchi  7 , A Mazzotta  7 , Y Narita  8 , H Sato  9 , Y Miyakita  10 , O Shamieh  11 , W Alrjoob  12 , A Pace  13 , D Petranovic  14 , M Ploh  14 , A Capela  15 , J Silva  15 , M J Hjermstad  16 , T Urbanic Purkart  17 , C Seidel  18 , N Talhi  18 , J Pichler  19 , I Höllmüller  19 , L Brown  20 , M Hand  20 , M Klein  21 , N K Aaronson  22 , B M J Uitdehaag  23 , M J B Taphoorn  24 , L Dirven  4 ; EORTC Quality of Life Group and the EORTC Brain Tumor Group
Affiliations
Free article
Multicenter Study

Instrumental activities of daily living in neuro-oncology: International validation of the EORTC IADL-BN32 questionnaire

Q Oort et al. Eur J Cancer. 2024 Nov.
Free article

Abstract

Background: Neurocognitive impairments are common in patients with a brain tumour, and may negatively impact on functioning in daily life, particularly on instrumental activities of daily living (IADL). The EORTC IADL-BN32 questionnaire was developed to measure IADL in this patient population.

Methods: In this international validation study, we evaluated the EORTC IADL-BN32 questionnaire on several psychometric properties in a large sample of patients with a primary or metastatic brain tumour. We administered the 32-item questionnaire three times: at 'baseline', after 2 weeks and after 3 months. Procedures were in accordance with EORTC Quality of Life Group module development guidelines.

Results: In total, 326 patients participated in the study. A bifactor scale structure showed satisfactory model fit measures, with five multi-item scales and two single items, and an IADL sum score. The internal consistency of the multi-item scales ranged from good to excellent (range Cronbach's α: 0.86-0.97). We found significant differences in scale scores between patients with and without neurocognitive impairments or complaints, supporting the construct validity. Initial cross-cultural validity analyses showed indications of item response biases for certain items. Analyses indicated moderate to good test-retest agreement (intraclass correlation coefficient > 0.70) between baseline and the 2-week follow-up assessment for all but one scale. Deterioration of EORTC IADL-BN32 scale scores were consistent with clinically relevant deterioration on other functional measures with small to large effect sizes, however, subgroup sample sizes were small.

Conclusion: Overall, the EORTC IADL-BN32 questionnaire exhibited adequate to excellent psychometric properties. Cross-cultural validity and responsiveness should be further explored.

Keywords: Brain metastasis; Brain tumour; Daily functioning; Glioma; IADL; Instrumental activities of daily living.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources