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. 2024 Sep 27;25(1):320.
doi: 10.1186/s12882-024-03757-x.

Association of obesity severity and duration with incidence of chronic kidney disease

Faranak Ghazy  1 , Navid Ebrahimi  1 , Amir Ebadinejad  2 , Maryam Barzin  1 , Maryam Mahdavi  1 , Majid Valizadeh  1 , Fereidoun Azizi  3 , Farhad Hosseinpanah  4
Affiliations

Association of obesity severity and duration with incidence of chronic kidney disease

Faranak Ghazy et al. BMC Nephrol. .

Abstract

Introduction: Obesity is a known risk factor for chronic kidney disease (CKD), but the impact of obesity severity and duration on CKD incidence is unclear.

Methods: Cumulative Excess Weight (CEW) and Cumulative Excess Waist Circumference (CEWC) scores were calculated, which represent the accumulation of deviations from expected body mass index and waist circumference values over time until the development of CKD or the end of the follow-up period. Time-dependent Cox models were used to investigate the sex-stratified association of CEW and CEWC with CKD incidence while controlling for confounding variables.

Results: Out of the 8697 participants who were evaluated in this study, 56% (4865) were women and the mean age was 40 ± 14. During the 15-year follow-up period, 41.7% (3629) of the participants developed CKD. Among the CKD patients, 65.4% (829) of men and 77.9% (1839) of women had a BMI higher than 25, and high WC was found to be 73.7% (934) and 55.3% (1306) for men and women, respectively. We found a significant association between one standard deviation change of CEW and the development of CKD in both sexes (fully adjusted hazard ratios and 95% CI of CEW in men and women were 1.155 [1.081-1.232) and 1.105 (1.047-1.167)]. However, the association between CEWC and CKD development was only significant among men participants [HR = 1.074 (1.006-1.147)].

Conclusion: Over a 15-year follow-up, the accumulation of general and central obesity was associated with an increased incidence of CKD development.

Keywords: Central obesity; Chronic kidney disease; Cumulative excess waist circumference; Cumulative excess weight; General obesity.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the selection process of patients
See this image and copyright information in PMC

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