Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Dec 8;2(6203):1461-6.
doi: 10.1136/bmj.2.6203.1461.

Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs

L J Kinlen, A G Sheil, J Peto, R Doll

Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs

L J Kinlen et al. Br Med J. .

Abstract

A collaborative study including centres in the United Kingdom, Australia, and New Zealand was instituted in 1970 to determine the incidence of cancer in patients treated for at least three months with azathioprine, cyclophosphamide, or chlorambucil. Follow-up of 3823 renal transplant recipients showed an almost 60-fold increase of non-Hodgkin's lymphoma together with an excess of squamous-cell skin cancer and mesenchymal tumours. A series of 1349 patients without transplants showed an excess of the same tumours, though to a less extent. These preliminary findings provide no clear evidence that immunosuppressive drugs produce the increased risk of most of the common cancers that might be expected from the simplest interpretation of impaired "immunosurveillance."

PubMed Disclaimer

References

    1. Br Med J. 1965 Feb 6;1(5431):338-42 - PubMed
    1. Lancet. 1971 Dec 11;2(7737):1282-3 - PubMed
    1. J Chronic Dis. 1978;31(11):691-6 - PubMed
    1. Br Med J. 1968 Dec 21;4(5633):746-8 - PubMed
    1. Transplant Proc. 1969 Mar;1(1):106-12 - PubMed

MeSH terms

LinkOut - more resources