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Review
. 2024 Sep 3;12(9):2011.
doi: 10.3390/biomedicines12092011.

Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma

Gabriella E Wilson  1 , Samir Gautam  1 , Geoffrey L Chupp  1
Affiliations
Review

Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma

Gabriella E Wilson et al. Biomedicines. .

Abstract

This review provides an overview of evidence supporting the existence of distinct homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular emphasis is placed on describing the phenotypic and functional roles of these eosinophil subtypes in asthma, as well as the phenotypic changes induced by clinical therapy with the anti-IL-5 biologic agent, mepolizumab. Improved understanding of distinct eosinophil phenotypes may enable targeting of select subpopulations in the treatment of patients with type 2 inflammatory diseases such as asthma.

Keywords: asthma; eosinophils; inflammatory eosinophils; interleukin-5.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The Eosinophil life cycle. (A) The bone marrow phase of the eosinophil life cycle; (B) the blood phase of the eosinophil life cycle; and (C) the tissue phase of the eosinophil life cycle. Created with BioRender.com.
Figure 2
Figure 2
Airway eosinophil subpopulation phenotypes and functions, * indicates markers identified from murine studies. Created with BioRender.com.
See this image and copyright information in PMC

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