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. 2024 Aug 30;60(9):1421.
doi: 10.3390/medicina60091421.

External Validation of the New 2023 International Federation of Gynecology and Obstetrics Staging System in Endometrial Cancer Patients: 12-Year Experience from an European Society of Gynecological Oncology-Accredited Center

Dimitrios Tsolakidis  1 , Dimitrios Zouzoulas  1 , Iliana Sofianou  1 , Tilemaxos Karalis  1 , Kimon Chatzistamatiou  1 , Vasilis Theodoulidis  1 , Maria Topalidou  2 , Eleni Timotheadou  3 , Grigoris Grimbizis  1
Affiliations

External Validation of the New 2023 International Federation of Gynecology and Obstetrics Staging System in Endometrial Cancer Patients: 12-Year Experience from an European Society of Gynecological Oncology-Accredited Center

Dimitrios Tsolakidis et al. Medicina (Kaunas). .

Abstract

Background and Objectives: The new molecular classification of endometrial cancer continuously changes the management of the disease in everyday clinical practice. Recently, FIGO released a new staging system for endometrial cancer, which incorporates molecular substages and subdivides further early-stage disease. The aim of this study was to investigate the differences between the two FIGO staging systems and evaluate the prognostic precision of the new one. Materials and Methods: We retrospectively analyzed the records of patients with endometrial cancer that were fully treated in the 1st Department of Obstetrics & Gynecology, in 2012-2023. Patient characteristics, oncological outcome, and follow-up information were collected. The primary outcomes were the stage shifts and the survival data. Results: Sixty-seven (15.5%) patients had a stage shift and the majority of them concerned early-stage disease and specifically an upshift from 2009 stages IA and IB to 2023 stage IIC. Concerning survival, a better median and 5-year PFS was present in stage II disease, and when comparing the prognostic precision of the two FIGO staging systems no significant difference was present. Conclusions: The new 2023 FIGO staging system better distinguishes early-stage endometrial cancer into its prognostic groups and seems to be as precise as the old 2009 FIGO staging system.

Keywords: cancer staging; endometrial cancer; prognosis; survival.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Early-stage disease Shankey plot for stage shifts between 2009 and 2023 FIGO staging systems.
Figure 2
Figure 2
Advanced-stage disease Shankey plot for stage shifts between 2009 and 2023 FIGO staging systems.
Figure 3
Figure 3
PFS for 2009 and 2023 FIGO staging systems (no molecular classification).
Figure 4
Figure 4
OS for 2009 and 2023 FIGO staging systems (no molecular classification).
See this image and copyright information in PMC

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