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. 2024 Sep 12;13(18):5395.
doi: 10.3390/jcm13185395.

The Collaborative Outcome Study on Health and Functioning during Infection Times (COH-FIT): Results from Cyprus

Affiliations

The Collaborative Outcome Study on Health and Functioning during Infection Times (COH-FIT): Results from Cyprus

Evangelia Papatriantafyllou et al. J Clin Med. .

Abstract

Many studies have shown that COVID-19 caused many problems in mental health. This paper presents the results of the Cyprus sample, part of the global initiative named "The Collaborative Outcomes Study on Health and Functioning during Infection Times" (COH-FIT). Methods: The study took place from April 2019 to January 2022, using the Greek version of the online standard COH-FIT questionnaire on 917 Cypriot adults. Weighted t-tests were applied to test the differences between pre-pandemic and intra-pandemic scores using the anesrake package. Results: Participant responses indicated a significant negative impact of the pandemic on measures of mental health (-7.55; 95% CI: -9.01 to -6.07), with worsening in the scores for anxiety (12.05; 95% CI: 9.33 to 14.77), well-being (-11.06; 95% CI: -12.69 to -9.45) and depression (4.60; 95% CI: 2.06 to 7.14). Similar negative effects were observed for feelings of anger (12.92; 95% CI: 10.54 to 15.29), helplessness (9.66; 95% CI: 7.25 to 12.07), fear (22.25; 95% CI: 19.25 to 25.26), and loneliness (12.52; 95% CI: 9.94 to15.11). Increased use of social media (0.89; 95% CI: 0.71 to 1.09), internet (0.86; 95% CI: 0.67 to 1.04), and substance consumption (0.06; 95% CI: 0.00 to 0.11) were reported, along with a significant decrease in physical health (-3.45; 95% CI: -4.59 to -2.32), self-care (-7.10; 95% CI: -9.00 to -5.20), and social function (-11.27; 95% CI: -13.19 to -9.35), including support (-0.72; 95% CI: -1.09 to -0.34) and family function (-7.97; 95% CI: -9.90 to -6.05). Conclusions: The COVID-19 pandemic significantly affected the daily life and emotional well-being of Cypriots. Identifying factors that influence vulnerability and resilience is essential to prioritize mental health support and address the long-term effects of the pandemic.

Keywords: COVID-19 pandemic; Cyprus; global health crisis; mental health; well-being.

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Conflict of interest statement

Marco Solmi has received honoraria/served as a consultant/participated to advisory board for Angelini, Lundbeck, Otsuka. CU Correll has been a consultant and/or advisor to or has received honoraria from: AbbVie, Acadia, Adock Ingram, Alkermes, Allergan, Angelini, Aristo, Biogen, Boehringer-Ingelheim, Bristol-Meyers Squibb, Cardio Diagnostics, Cerevel, CNX Therapeutics, Compass Pathways, Darnitsa, Delpor, Denovo, Eli Lilly, Gedeon Richter, Hikma, Holmusk, IntraCellular Therapies, Jamjoom Pharma, Janssen/J&J, Karuna, LB Pharma, Lundbeck, MedInCell, MedLink, Merck, Mindpax, Mitsubishi Tanabe Pharma, Maplight, Mylan, Neumora Therapeutics, Neurocrine, Neurelis, Newron, Noven, Novo Nordisk, Otsuka, PPD Biotech, Recordati, Relmada, Reviva, Rovi, Sage, Saladax, Sanofi, Seqirus, SK Life Science, Sumitomo Pharma America, Sunovion, Sun Pharma, Supernus, Tabuk, Takeda, Teva, Terran, Tolmar, Vertex, Viatris and Xenon Pharmaceuticals. He provided expert testimony for Janssen, Lundbeck and Otsuka. He served on a Data Safety Monitoring Board for Compass Pathways, Denovo, IntraCellular Therapies, Lundbeck, Relmada, Reviva, Rovi, Supernus, and Teva. He has received grant support from Boehringer-Ingelheim, Janssen and Takeda. He received royalties from UpToDate and is also a stock option holder of Cardio Diagnostics, Kuleon Biosciences, LB Pharma, Medlink, Mindpax, Quantic, Terran. Other authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Plots of mental health outcomes of adult Cypriots (N = 917) on the Collaborative Outcome Study on Health and Functioning During Infection Times (COH-FIT) questionnaire [(A): Anxiety, (B): Depression, (C): Stress, (D): Post-traumatic symptoms, (E): Obsessive-compulsive symptoms, (F): Mania]. Symptoms presented as raw and weighted data, applying the raking method. Green lines show the intra-pandemic period, blue lines show pre-pandemic period, and red lines show the change from baseline as functions of time. The gray lines show the confidence intervals (95% CIs) and are darker when they overlap. p-values for the association between time and CFB are also displayed alongside the corresponding coefficients and 95% confidence intervals; coefficients’ estimates and confidence intervals denote changes per month.
Figure 2
Figure 2
Plots of health outcomes of adult Cypriots (N = 917) on the Collaborative Outcome Study on Health and Functioning During Infection Times (COH-FIT) questionnaire [(A): Well-being, (B): P-score, (C): P-extended score, (D): Global health, (E): Mental health, (F): Self-care] presented as raw and weighted data, after applying the raking method. Green lines show the intra-pandemic period, blue lines show pre-pandemic period, and red lines show the change from baseline as functions of time. The gray lines show the confidence intervals (95% CIs) and are darker when they overlap. p-values for the association between time and CFB are also displayed alongside the corresponding coefficients and 95% confidence intervals; coefficients’ estimates and confidence intervals denote changes per month.

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