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Review
. 2024 Sep 13;16(9):1201.
doi: 10.3390/pharmaceutics16091201.

Applications of Chitosan in Prevention and Treatment Strategies of Infectious Diseases

Genada Sinani  1 , Melike Sessevmez  2 , Sevda Şenel  3
Affiliations
Review

Applications of Chitosan in Prevention and Treatment Strategies of Infectious Diseases

Genada Sinani et al. Pharmaceutics. .

Abstract

Chitosan is the most commonly investigated functional cationic biopolymer in a wide range of medical applications due to its promising properties such as biocompatibility, biodegradability, and bioadhesivity, as well as its numerous bioactive properties. Within the last three decades, chitosan and its derivatives have been investigated as biomaterials for drug and vaccine delivery systems, besides for their bioactive properties. Due to the functional groups in its structure, it is possible to tailor the delivery systems with desired properties. There has been a great interest in the application of chitosan-based systems also for the prevention and treatment of infectious diseases, specifically due to their antimicrobial, antiviral, and immunostimulatory effects. In this review, recent applications of chitosan in the prevention and treatment of infectious diseases are reviewed, and possibilities and limitations with regards to technical and regulatory aspects are discussed. Finally, the future perspectives on utilization of chitosan as a biomaterial are discussed.

Keywords: chitosan; delivery system; infections; nanoparticles; vaccine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structure of chitin (a) and chitosan (b,c).
Figure 2
Figure 2
Potential of chitosan for prevention and treatment of infectious diseases.
See this image and copyright information in PMC

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