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Review
. 2024 Sep 10;29(18):4294.
doi: 10.3390/molecules29184294.

Application of Intelligent Response Fluorescent Probe in Breast Cancer

Anqi Sheng  1   2 , Hao Zhang  1 , Qing Li  2 , Shu Chen  2 , Qingshuang Wang  1
Affiliations
Review

Application of Intelligent Response Fluorescent Probe in Breast Cancer

Anqi Sheng et al. Molecules. .

Abstract

As one of the leading cancers threatening women's lives and health, breast cancer is challenging to treat and often irreversible in advanced cases, highlighting the critical importance of early detection and intervention. In recent years, fluorescent probe technology, a revolutionary in vivo imaging tool, has gained attention in medical research for its ability to improve tumor visualization significantly. This review focuses on recent advances in intelligent, responsive fluorescent probes, particularly in the field of breast cancer, which are divided into five categories, near-infrared responsive, fluorescein-labeled, pH-responsive, redox-dependent, and enzyme-triggered fluorescent probes, each of which has a different value for application based on its unique biological response mechanism. In addition, this review also covers the strategy of combining fluorescent probes with various anti-tumor drugs, aiming to reveal the possibility of synergistic effects between the two in breast cancer treatment and provide a solid theoretical platform for the clinical translation of fluorescent probe technology, which is expected to promote the expansion of cancer treatment technology.

Keywords: application; breast cancer; fluorescent probes; synthesis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structural synthesis of the NIR-II fluorescent probe BP-A and the mechanism of response to H2S [24]. Copyright 2023, ELSEVIER.
Figure 2
Figure 2
(A) Fluorescence imaging of exogenous H2S in non-homozygous mice. (B) Relative fluorescence intensity. (C) Fluorescence imaging of exogenous H2S in hormonal mice. (D) Relative fluorescence intensity [24]. Copyright 2023, ELSEVIER.
Figure 3
Figure 3
Sensing mechanism of TPQ-G (A) and its synthesis (B) [47]. Copyright 2022, ELSEVIER.
Figure 4
Figure 4
Synthesis of endoplasmic reticulum-targeted fluorescent probe N-Se and its redox reaction process [48].
Figure 5
Figure 5
Schematic of enzyme cascade-based ratiometric fluorescent probes for visually monitoring ALP activity. Copyright 2021, ELSEVIER.
See this image and copyright information in PMC

References

    1. Yang R.Z., Han Y., Yi W.J., Long Q. Autoantibodies as biomarkers for breast cancer diagnosis and prognosis. Front. Immunol. 2022;13:17. doi: 10.3389/fimmu.2022.1035402. - DOI - PMC - PubMed
    1. Liu M., Li Z.Y., Yang J.J., Jiang Y., Chen Z., Ali Z., Wang Z. Cell-specific biomarkers and targeted biopharmaceuticals for breast cancer treatment. Cell Prolif. 2016;49:409–420. doi: 10.1111/cpr.12266. - DOI - PMC - PubMed
    1. Lu B.Y., Natarajan E., Raghavendran H.R.B., Markandan U.D. Molecular Classification, Treatment, and Genetic Biomarkers in Triple-Negative Breast Cancer: A Review. Technol. Cancer Res. Treat. 2023;22:10. doi: 10.1177/15330338221145246. - DOI - PMC - PubMed
    1. Wu Y.Y., Feng Y.Q., Li X. Classification of breast cancer by a gold nanoparticle based multicolor fluorescent aptasensor. J. Colloid. Interface Sci. 2022;611:287–293. doi: 10.1016/j.jcis.2021.12.039. - DOI - PubMed
    1. Harbeck N., Gnant M. Breast cancer. Lancet. 2017;389:1134–1150. doi: 10.1016/S0140-6736(16)31891-8. - DOI - PubMed

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