Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 11;16(18):3070.
doi: 10.3390/nu16183070.

Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19

Anabel González-Acedo  1 , Francisco Javier Manzano-Moreno  2   3 , Enrique García-Recio  1   3 , Concepción Ruiz  1   3   4 , Elvira de Luna-Bertos  1   3 , Víctor Javier Costela-Ruiz  1   3
Affiliations
Review

Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19

Anabel González-Acedo et al. Nutrients. .

Abstract

Consequences of the disease produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to an urgent search for preventive and therapeutic strategies. Besides drug treatments, proposals have been made for supplementation with biomolecules possessing immunomodulatory and antioxidant properties. The objective of this study was to review published evidence on the clinical usefulness of supplementation with vitamin D, antioxidant vitamins (vitamin A, vitamin E, and vitamin C), melatonin, lactoferrin and natural products found in food (curcumin, luteolin, ginger, allicin, magnesium and zinc) as supplements in SARS-CoV-2 infection. In general, supplementation of conventional treatments with these biomolecules has been found to improve the clinical symptoms and severity of the coronavirus disease (COVID-19), with some indications of a preventive effect. In conclusion, these compounds may assist in preventing and/or improving the symptoms of COVID-19. Nevertheless, only limited evidence is available, and findings have been inconsistent. Further investigations are needed to verify the therapeutic potential of these supplements.

Keywords: COVID-19; antioxidant vitamins; lactoferrin; melatonin; vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

References

    1. Aimrane A., Laaradia M.A., Sereno D., Perrin P., Draoui A., Bougadir B., Hadach M., Zahir M., Fdil N., El Hiba O., et al. Insight into COVID-19’s Epidemiology, Pathology, and Treatment. Heliyon. 2022;8:e08799. doi: 10.1016/j.heliyon.2022.e08799. - DOI - PMC - PubMed
    1. World Health Organization. Coronavirus Disease (COVID-19). World Health Organization: Geneva, Switzerland. 2023. [(accessed on 3 August 2024)]. Available online: http://www.who.int/es/news-room/fact-sheets/detail/coronavirus-disease-(...
    1. Yesudhas D., Srivastava A., Gromiha M.M. COVID-19 Outbreak: History, Mechanism, Transmission, Structural Studies and Therapeutics. Infection. 2021;49:199–213. doi: 10.1007/s15010-020-01516-2. - DOI - PMC - PubMed
    1. Mouffak S., Shubbar Q., Saleh E., El-Awady R. Recent Advances in Management of COVID-19: A Review. Biomed. Pharmacother. 2021;143:112107. doi: 10.1016/j.biopha.2021.112107. - DOI - PMC - PubMed
    1. Hamming I., Timens W., Bulthuis M.L.C., Lely A.T., Navis G.J., van Goor H. Tissue Distribution of ACE2 Protein, the Functional Receptor for SARS Coronavirus. A First Step in Understanding SARS Pathogenesis. J. Pathol. 2004;203:631–637. doi: 10.1002/path.1570. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources