Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 19;16(18):3168.
doi: 10.3390/nu16183168.

Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health

You-Lin Tain  1   2   3 , Chien-Ning Hsu  4   5
Affiliations
Review

Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health

You-Lin Tain et al. Nutrients. .

Abstract

Background: The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to the recognition of cardiovascular-kidney-metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, a group of phytochemicals, have demonstrated potential health-promoting effects.

Methods: This review highlights the impact of maternal polyphenol supplementation on the CKM health of offspring.

Results: Initially, we summarize the interconnections between polyphenols and each aspect of CKM syndrome. We then discuss in vivo studies that have investigated the use of polyphenols during pregnancy and breastfeeding, focusing on their role in preventing CKM syndrome in offspring. Additionally, we explore the common mechanisms underlying the protective effects of maternal polyphenol supplementation.

Conclusions: Overall, this review underscores the potential of early-life polyphenol interventions in safeguarding against CKM syndrome in offspring. It emphasizes the importance of continued research to advance our understanding and facilitate the clinical translation of these interventions.

Keywords: cardiovascular disease; developmental origins of health and disease (DOHaD); gut microbiota; hypertension; kidney disease; metabolic syndrome; polyphenols; resveratrol.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Polyphenol classes and main compounds.
Figure 2
Figure 2
Metabolic fates of dietary polyphenols in the body involve several stages: phase I and II metabolism in the gut and liver, microbial metabolism, absorption into systemic circulation, interaction with target organs, and eventual elimination through feces and urine.
Figure 3
Figure 3
Schema outlining the protective mechanisms of polyphenols behind cardiovascular–kidney–metabolic syndrome with developmental origins.
See this image and copyright information in PMC

References

    1. Roth G.A., Mensah G.A., Johnson C.O., Addolorato G., Ammirati E., Baddour L.M., Barengo N.C., Beaton A.Z., Benjamin E.J., Benziger C.P., et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. J. Am. Coll. Cardiol. 2020;76:2982–3021. doi: 10.1016/j.jacc.2020.11.010. - DOI - PMC - PubMed
    1. Ndumele C.E., RAngaswami J., Chow S.L., Neeland I.J., Tuttle K.R., Khan S.S., Coresh J., Mathew R.O., Baker-Smith C.M., Carnethon M.R., et al. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory from the American Heart Association. Circulation. 2023;148:1606–1635. doi: 10.1161/CIR.0000000000001184. - DOI - PubMed
    1. Jaradat J.H., Nashwan A.J. Cardiovascular-kidney-metabolic syndrome: Understanding the interconnections and the need for holistic intervention. J. Med. Surg. Public Health. 2023;1:100028. doi: 10.1016/j.glmedi.2023.100028. - DOI
    1. Hanson M., Gluckman P. Developmental origins of noncommunicable disease: Population and public health implications. Am. J. Clin. Nutr. 2011;94:1754S–1758S. doi: 10.3945/ajcn.110.001206. - DOI - PubMed
    1. Fleming T.P., Velazquez M.A., Eckert J.J. Embryos, DOHaD and David Barker. J. Dev. Orig. Health Dis. 2015;6:377–383. doi: 10.1017/S2040174415001105. - DOI - PubMed

LinkOut - more resources