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. 2024 Aug 30;12(9):995.
doi: 10.3390/vaccines12090995.

Production and Evaluation of an Inactivated Adjuvanted Vaccine against Canine Parvovirus in Morocco

Ghizlane Sebbar  1 , Safae El Azhari  1 , Mourad Drifa  1 , Said Mouhri  1 , Mustapha Hammouchi  1 , Hajar Moudhich  1 , Chafiqa Loutfi  1 , Farid Amraoui  1
Affiliations

Production and Evaluation of an Inactivated Adjuvanted Vaccine against Canine Parvovirus in Morocco

Ghizlane Sebbar et al. Vaccines (Basel). .

Abstract

The study conducted in Morocco focused on addressing the challenges posed by canine parvovirus (CPV-2) through comprehensive research, vaccine development, and efficacy assessment. Through real-time PCR screening and genotyping, CPV-2 variants were identified circulating in the region. An inactivated vaccine, derived from a CPV-2 strain isolated from a symptomatic dog, was produced and evaluated for safety and efficacy. The vaccine, from the strain named "CaPV M/3-2022", demonstrated safety in vaccinated puppies, with no adverse reactions observed during the trial period. Efficacy trials showed that vaccinated puppies remained healthy and exhibited lower viral excretion post-challenge compared to unvaccinated controls. These results indicate that the vaccine effectively protects against illness related to CPV-2 and reduces viral shedding. The study provides valuable insights into CPV-2 epidemiology in Morocco, offers a promising vaccine solution, and underscores the importance of vaccination in controlling CPV-2 outbreaks and protecting canine health.

Keywords: Morocco; canine parvovirus; inactivated adjuvanted vaccine; isolation; puppies; real-time PCR.

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Conflict of interest statement

All authors are employed by BIOPHARMA. The employer had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, nor in the decision to publish the results. All has been achieved through the principle of impartiality.

Figures

Figure 1
Figure 1
Body temperature monitoring curves. D: day.
Figure 2
Figure 2
White blood cell rate per mm3 for each puppy. D: day.
See this image and copyright information in PMC

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