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. 2024 Oct;45(10):729-731.
doi: 10.1016/j.it.2024.09.004. Epub 2024 Sep 27.

Feeding the wrath with myelin

Sourav Ghosh  1 , Carla V Rothlin  2
Affiliations

Feeding the wrath with myelin

Sourav Ghosh et al. Trends Immunol. 2024 Oct.

Abstract

Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.

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Conflict of interest statement

Declaration of interests C.V.R. is a member of the Trends in Immunology Advisory Board.

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