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. 2024 Sep 28;14(1):22490.
doi: 10.1038/s41598-024-73395-8.

Incidence and risk factor analysis of neovascular glaucoma following vitrectomy in patients with proliferative diabetic retinopathy

Sunjin Hwang #  1 , Ji Hong Kim #  2 , Yeon Hee Choi  1 , Zheng Xian Thng  3 , Eun Hee Hong  1 , Min Ho Kang  1 , Yong Un Shin  4
Affiliations

Incidence and risk factor analysis of neovascular glaucoma following vitrectomy in patients with proliferative diabetic retinopathy

Sunjin Hwang et al. Sci Rep. .

Abstract

To investigate the incidence and risk factors for neovascular glaucoma (NVG) after vitrectomy in patients with proliferative diabetic retinopathy (PDR). Patients were categorized into two subgroups based on their treatment regimen: one group received vitrectomy only (Group 1), while the other received combined phacovitrectomy (Group 2). A comparative analysis was conducted to evaluate the distinguishing characteristics of the two groups. Kaplan-Meier survival analysis was used to determine the incidence of NVG following surgery. Furthermore, multivariate analysis using the Cox proportional hazards model was conducted to identify the risk factors associated with the development of NVG after surgery. A total of 484 eyes of 484 patients were included in the study. When comparing Group 1 with Group 2, a significant difference was observed in the occurrence of NVG. In Group 1, there were 10 cases of NVG (3.9%), whereas 29 cases of NVG occurred in Group 2 (12.71%). Male sex, high preoperative intraocular pressure (IOP), and combined phacovitrectomy were found to be associated with the occurrence of NVG following phacovitrectomy. Higher creatinine levels had a protective effect in preventing the development of NVG. Male sex, high preoperative IOP, and combined phacovitrectomy were associated with a high incidence of NVG. Explore strategies to prevent NVG is important when performing combined phacovitrectomy in patients with PDR.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The cumulative probability of neovascular glaucoma (NVG) following surgery is graphically represented for Group 1 and Group 2. The horizontal axis displays the time elapsed post-surgery in months, while the vertical axis shows the incidence of NVG in percentages. A significant difference in the incidence rate of NVG between Group 1 and Group 2 was observed (P < 0.001).
Fig. 2
Fig. 2
Flow chart of enrolled patients and exclusion.
See this image and copyright information in PMC

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