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. 2024 Sep 28;24(1):616.
doi: 10.1186/s12884-024-06789-1.

The association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study

Li-Yang Zhou #  1   2 , Zhou Xu #  3 , Li Wen  1 , Xin-Zhen Chen  1 , Ying-Ling Yao  1   2 , Rui-Ling Liu  1   2 , Yong-Jia Zhang  1   2 , Zhao-Hui Zhong  2 , Li-Juan Fu  2   4 , Gong-Li Chen  5 , Yu-Bin Ding  6   7
Affiliations

The association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study

Li-Yang Zhou et al. BMC Pregnancy Childbirth. .

Abstract

Background: Maternal lipid metabolism has been implicated in elevating the risk of adverse pregnancy outcomes, which is a particularly significant concern in twin pregnancies. However, the precise relationship between early pregnancy dyslipidemia and the risk of preterm birth (PTB) in twin pregnancies remains unclear.

Methods: This retrospective cohort study included women with twin pregnancies between January 2018 and December 2023. Early pregnancy blood lipid profiles, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), were examined. Dyslipidemia was diagnosed based on the diagnostic criteria outlined in the 2016 guidelines for the prevention and treatment of dyslipidemia in Chinese adults. PTB was defined as birth occurring before 37 weeks of pregnancy. Logistic regression models were used to evaluate the association of early pregnancy dyslipidemia with PTB in twin pregnancies.

Results: A total of 613 women with twin pregnancies were included, and 141 women were complicated with dyslipidemia. The incidence of PTB < 37 weeks was significantly higher in the dyslipidemia group compared to the group without dyslipidemia (64.5% vs. 50.4%, P = 0.003). After adjusting for confounding factors, dyslipidemia was positively associated with PTB < 37 weeks (adjusted odds ratio: 1.71; 95% confidence interval: 1.13-2.58). However, these associations varied depending on the chorionicity and mode of conception of the twins. The positive associations between early pregnancy dyslipidemia and PTB < 37 weeks remained significant only in spontaneously conceived (SC) or dichorionic diamniotic (DCDA) twin pregnancies. No statistically significant associations were observed between dyslipidemia and the other secondary outcomes.

Conclusion: Early pregnancy dyslipidemia was positively associated with PTB < 37 weeks in twin pregnancies, and this association remained significant in SC or DCDA twin pregnancies. Comprehensive lipid profile assessment in the first trimester may be beneficial for patients' monitoring and implementing interventions to mitigate adverse pregnancy outcomes.

Keywords: Dyslipidemia; Early pregnancy; Preterm birth; Twin pregnancy.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Hu DY. New guidelines and evidence for the prevention and treatment of dyslipidemia and atherosclerotic cardiovascular disease in China. Zhonghua Xin Xue Guan Bing Za Zhi. 2016;44(10):826–7. - PubMed
    1. Poornima IG, Indaram M, Ross JD, Agarwala A, Wild RA. Hyperlipidemia and risk for preclampsia. J Clin Lipidol. 2022;16(3):253–60. - PMC - PubMed
    1. Adank MC, Benschop L, van Streun SP, Smak Gregoor AM, Mulder MT, Steegers EAP, et al. Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study. BMC Med. 2020;18(1):394. - PMC - PubMed
    1. Ying C, Yue C, Zhang C, Li X. Analysis of serum lipids levels and the establishment of reference intervals for serum lipids in middle and late pregnancy. Zhonghua Fu Chan Ke Za Zhi. 2015;50(12):926–30. - PubMed
    1. Jin WY, Lin SL, Hou RL, Chen XY, Han T, Jin Y, et al. Associations between maternal lipid profile and pregnancy complications and perinatal outcomes: a population-based study from China. BMC Pregnancy Childbirth. 2016;16:60. - PMC - PubMed

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