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Meta-Analysis
. 2024 Sep 28;43(1):154.
doi: 10.1186/s41043-024-00645-w.

Association between caffeine intake and erectile dysfunction: a meta-analysis of cohort studies

Mehdi Karimi  1 , Omid Asbaghi  2 , Kimia Kazemi  3 , Fatemeh Maleki Sedgi  4 , Ensiye Soleimani  5 , Hanieh Keikhay Moghadam  6
Affiliations
Meta-Analysis

Association between caffeine intake and erectile dysfunction: a meta-analysis of cohort studies

Mehdi Karimi et al. J Health Popul Nutr. .

Abstract

Background: Erectile dysfunction (ED) is a common condition with various contributing factors, including lifestyle and dietary habits. Caffeine, a widely consumed stimulant, has been linked to multiple physiological effects on vascular function and hormonal balance that might influence sexual function. This meta-analysis aims to evaluate the association between caffeine intake and the risk of ED by analyzing data from cohort studies.

Methods: A systematic search was conducted across PubMed, Web of Science, Scopus, and Embase databases, and a manual search was conducted on Google Scholar for studies on the relationship between caffeine intake and ED in adult men. The search included observational studies published up to April 1, 2024. Four cohort studies were included, and their data were extracted and analyzed by STATA version 18.

Results: Four included cohort studies comprised 51,665 cohort members. The study population included adult males, on average, aged 18 to 80. The results indicate that there was no significant relationship between coffee consumption and the risk of ED (relative risk [RR] = 0.94, 95% CI: 0.86-1.03; p = 0.999).

Conclusions: The current evidence suggests no significant relationship between caffeine intake and ED, but limited studies limit conclusions. Future research should focus on larger sample sizes, standardized outcome assessments, and different dosages and forms of caffeine consumption.

Keywords: Caffeinated beverages; Caffeine; Coffee; Cohort; Erectile.

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Conflict of interest statement

The authors declare no conflict of interest.

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flowchart diagram
Fig. 2
Fig. 2
Forest plot of RR of ED for coffee consumption
Fig. 3
Fig. 3
Egger’s funnel plot for the risk of ED
See this image and copyright information in PMC

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