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. 2024 Sep 30;191(4):444-456.
doi: 10.1093/ejendo/lvae119.

NT-proBNP levels in patients with primary hyperaldosteronism and autonomous cortisol cosecretion

Anna Hirsch  1   2 , Christian Adolf  3 , Isabel Stüfchen  3 , Felix Beuschlein  3   4   5 , Denise Brüdgam  3 , Martin Bidlingmaier  3 , Martin Reincke  3 , Marcus Quinkler  1
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NT-proBNP levels in patients with primary hyperaldosteronism and autonomous cortisol cosecretion

Anna Hirsch et al. Eur J Endocrinol. .

Abstract

Context: Patients with primary aldosteronism (PA) have higher cardiac comorbidities including more pronounced left ventricular hypertrophy than patients with essential hypertension.

Objective: Autonomous cortisol cosecretion (ACS) is a common subtype in PA associated with a worse metabolic profile.

Hypothesis: Autonomous cortisol cosecretion may affect myocardial parameters and result in a worse cardiac outcome compared to patients with PA and without ACS.

Methods: Three hundred and sixty-seven patients with PA undergoing 1 mg dexamethasone suppression test (DST) and echocardiography at baseline from 2 centers of the German Conn's Registry were included. Follow-up for up to 3.8 years was available in 192 patients.

Results: Patients with PA and ACS had higher NT-proBNP levels at baseline compared to patients with PA without ACS (114 vs 75.6 pg/mL, P = .02), but showed no difference in echocardiography values. NT-proBNP levels showed a significant positive correlation (r = 0.141, P = .011) with cortisol levels after DST at baseline. In response to therapy of PA, NT-proBNP levels decreased, but remained significantly higher in patients with ACS compared to patients without ACS. At follow-up, left ventricle end-diastolic dimension (LVEDD) decreased significantly only in patients without ACS. Left atrial diameter (LAD) decreased significantly in patients without ACS and in female patients with ACS but not in male patients. Left ventricular mass index (LVMI) significantly improved in female patients without ACS but remained unchanged in female patients with ACS as well as in male patients at follow-up.

Conclusions: In patients with PA, concomitant ACS is associated with a worse cardiac profile and only partial recovery even years after initiation of targeted PA therapy.

Keywords: ACTH; Conn’s syndrome; aldosterone; cardiac comorbidity; dexamethasone suppression test; hypercortisolism; left ventricular hypertrophy; pro-BNP; renin.

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Conflict of interest statement

Conflict of interest: F.B. serves as incoming editor-in-chief of the European Journal of Endocrinology. The other authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.